PDF(Pubmed)
Abstract：
UNASSIGNED: Although SARS-CoV-2 vaccines have been developed with multiple novel technologies and rapidly disseminated worldwide, the full profile of adverse effects has not been known. Recently, there are sporadic but increasing reports of endocrinopathy in relation to SARS-CoV-2 vaccination. Here we report a rare case of hypophysitis with acute onset of diabetes insipidus, immediately after SARS-CoV-2 vaccination.
UNASSIGNED: A 48-year-old female patient had been in her usual state of health until she received the first SARS-CoV-2 vaccine. Two days after vaccination, she started to have flu-like symptoms, including severe headache and myalgia as well as persistent headache, polydipsia, and polyuria. She was diagnosed with diabetes insipidus, and magnetic resonance imaging revealed thickening of the pituitary stalk. Three months after vaccination, her symptoms had somewhat improved, but she still had pituitary stalk thickening on magnetic resonance imaging.
UNASSIGNED: Given the timing of the occurrence of diabetes insipidus, we believe that the patient\'s hypophysitis may be associated with SARS-CoV-2 vaccination. We also found 19 cases of endocrinopathy after SARS-CoV-2 vaccination by literature search. The reported endocrine organs were the thyroid, pituitary, and adrenals. Twelve cases of diabetes were also reported. Among 3 pituitary cases, diabetes insipidus was reported only in our case.
UNASSIGNED: We report a rare case of SARS-CoV-2 vaccine-triggered hypophysitis, which led to diabetes insipidus. SARS-CoV-2 vaccine-related endocrinopathy seems, indeed, possible. Endocrinopathy is associated with infrequent complications; however, it may be underestimated in the post-SARS-CoV-2-vaccinated population. Further studies are warranted to better understand SARS-CoV-2 vaccine-related endocrinopathy.
UNASSIGNED: A 48-year-old female patient had been in her usual state of health until she received the first SARS-CoV-2 vaccine. Two days after vaccination, she started to have flu-like symptoms, including severe headache and myalgia as well as persistent headache, polydipsia, and polyuria. She was diagnosed with diabetes insipidus, and magnetic resonance imaging revealed thickening of the pituitary stalk. Three months after vaccination, her symptoms had somewhat improved, but she still had pituitary stalk thickening on magnetic resonance imaging.
UNASSIGNED: Given the timing of the occurrence of diabetes insipidus, we believe that the patient\'s hypophysitis may be associated with SARS-CoV-2 vaccination. We also found 19 cases of endocrinopathy after SARS-CoV-2 vaccination by literature search. The reported endocrine organs were the thyroid, pituitary, and adrenals. Twelve cases of diabetes were also reported. Among 3 pituitary cases, diabetes insipidus was reported only in our case.
UNASSIGNED: We report a rare case of SARS-CoV-2 vaccine-triggered hypophysitis, which led to diabetes insipidus. SARS-CoV-2 vaccine-related endocrinopathy seems, indeed, possible. Endocrinopathy is associated with infrequent complications; however, it may be underestimated in the post-SARS-CoV-2-vaccinated population. Further studies are warranted to better understand SARS-CoV-2 vaccine-related endocrinopathy.
摘要：
尽管SARS-CoV-2疫苗已被开发出多种新技术并迅速在全球范围内传播，不良反应的全貌尚不清楚.最近,与SARS-CoV-2疫苗接种有关的内分泌疾病的报道零星但不断增加。在这里，我们报告了一例罕见的伴有尿崩症急性发作的垂体炎，SARS-CoV-2疫苗接种后立即接种。
一名48岁的女性患者一直处于正常的健康状况，直到她接种了第一支SARS-CoV-2疫苗。接种疫苗两天后，她开始出现流感样症状,包括严重的头痛和肌痛以及持续性头痛，多饮,和多尿。她被诊断出患有尿崩症,磁共振成像显示垂体柄增厚。接种疫苗三个月后，她的症状有所改善，但磁共振成像显示垂体柄仍然增厚.
■考虑到尿崩症的发生时间，我们认为患者的垂体炎可能与SARS-CoV-2疫苗接种有关。通过文献检索，我们还发现了19例SARS-CoV-2疫苗接种后的内分泌疾病。报告的内分泌器官是甲状腺，垂体,和肾上腺。还报告了12例糖尿病。在3例垂体病例中，仅在我们的病例中报告了尿崩症。
■我们报告了一例罕见的SARS-CoV-2疫苗引发的垂体炎，导致尿崩症.SARS-CoV-2疫苗相关的内分泌病似乎，的确,可能。内分泌病与罕见的并发症有关;然而，在SARS-CoV-2疫苗接种后的人群中可能被低估了。需要进一步的研究以更好地了解SARS-CoV-2疫苗相关的内分泌病。
一名48岁的女性患者一直处于正常的健康状况，直到她接种了第一支SARS-CoV-2疫苗。接种疫苗两天后，她开始出现流感样症状,包括严重的头痛和肌痛以及持续性头痛，多饮,和多尿。她被诊断出患有尿崩症,磁共振成像显示垂体柄增厚。接种疫苗三个月后，她的症状有所改善，但磁共振成像显示垂体柄仍然增厚.
■考虑到尿崩症的发生时间，我们认为患者的垂体炎可能与SARS-CoV-2疫苗接种有关。通过文献检索，我们还发现了19例SARS-CoV-2疫苗接种后的内分泌疾病。报告的内分泌器官是甲状腺，垂体,和肾上腺。还报告了12例糖尿病。在3例垂体病例中，仅在我们的病例中报告了尿崩症。
■我们报告了一例罕见的SARS-CoV-2疫苗引发的垂体炎，导致尿崩症.SARS-CoV-2疫苗相关的内分泌病似乎，的确,可能。内分泌病与罕见的并发症有关;然而，在SARS-CoV-2疫苗接种后的人群中可能被低估了。需要进一步的研究以更好地了解SARS-CoV-2疫苗相关的内分泌病。
