Abstract：
Alpha-bisabolol (α-bisabolol), an unsaturated monocyclic sesquiterpene alcohol, is known as one of the \"most-used herbal constituents\" in the world. Various therapeutic and biological properties of α-bisabolol in preventing oxidative stress, inflammatory disorders, infections, neurodegenerative diseases, cancers, and metabolic disorders have been reported. In this review, we evaluated new findings regarding the molecular mechanisms of α-bisabolol published from 2010 until 2021 in PubMed, Science Direct, and Scopus. The antioxidant mechanism of α-bisabolol is mainly associated with the reduction of ROS/RNS, MDA, and GSH depletion, MPO activity, and augmentation of SOD and CAT. Additionally, upregulating the expression of bcl-2 and suppression of bax, P53, APAF-1, caspase-3, and caspase-9 activity indicates the anti-apoptotic effects of α- bisabolol. It possesses anti-inflammatory effects via reduction of TNF-α, IL-1β, IL-6, iNOS, and COX-2 and suppresses the activation of ERK1/2, JNK, NF-κB, and p38. The antimicrobial effect is mediated by inhibiting the viability of infected cells and improves cognitive function via downregulation of bax, cleaved caspases-3 and 9 levels, β-secretase, cholinesterase activities, and upregulation of bcl-2 levels. Finally, due to multiple biological activities, α-bisabolol is worthy to be subjected to clinical trials to achieve new insights into its beneficial effects on human health.
摘要：
α-没药醇（α-没药醇），不饱和单环倍半萜醇，被称为世界上“最常用的草药成分”之一。α-没药醇在预防氧化应激方面的各种治疗和生物学特性，炎症性疾病，感染,神经退行性疾病，癌症,和代谢紊乱的报道。在这次审查中,我们评估了2010年至2021年在PubMed上发表的关于α-没药醇分子机制的新发现，科学直接，还有Scopus.α-红没药醇的抗氧化机制主要与减少ROS/RNS,MDA,和GSH消耗，MPO活动,以及SOD和CAT的增加。此外,上调bcl-2的表达和bax的抑制，P53、APAF-1、胱天蛋白酶-3和胱天蛋白酶-9活性表明α-红没药醇的抗凋亡作用。它通过减少TNF-α具有抗炎作用，IL-1β,IL-6,iNOS,和COX-2，并抑制ERK1/2，JNK，NF-κB,p38抗微生物作用是通过抑制感染细胞的活力来介导的，并通过下调bax来改善认知功能，裂解的caspases-3和9水平，β-分泌酶,胆碱酯酶活性，和Bcl-2水平上调。最后,由于多种生物活性，α-没药醇值得进行临床试验，以对其对人类健康的有益作用有新的见解。
