Abstract：
Chronic interstitial pneumonia (CIP) is a main pathology of sheep infected with small ruminant lentivirus (SRLV). Caprine arthritis-encephalitis (CAE) is caused by the same pathogen; however, the presence of CIP has been only occasionally reported in SRLV-infected goats. We carried out a cross-sectional study to determine the prevalence of histopathological lesions indicative of CIP in goats with symptomatic CAE, and to investigate whether CIP was associated with a higher prevalence of other types of pneumonia (purulent bronchopneumonia, fibrinous pleuropneumonia) or bacterial infections. Lung specimens and bronchial swabs were collected for histopathological and bacteriological examination, respectively, from 116 goats from a CAE-affected herd. All goats were euthanized due to severe clinical signs of CAE. The goats were seropositive for SRLV infection in two different ELISAs and the presence of SRLV antigen in the lung tissue was confirmed by immunohistochemistry. Histopathologically, pneumonia of any type was confirmed in 82 goats (70.7%) and CIP was present in 67 goats (57.8%). In most goats, the severity of the histopathological features of pneumonia was mild. Bacteria were detected in bronchial swabs from 73 goats (62.9%). CIP proved to be significantly positively linked to the occurrence of purulent bronchopneumonia (p < 0.001), fibrinous pleuropneumonia (p = 0.001), and of the infection of lungs with bacteria capable of causing pneumonia (p = 0.050). The causal character of these associations should be considered and warrants further investigation.
摘要：
慢性间质性肺炎(CIP)是绵羊沾染小反刍动物慢病毒(SRLV)的主要病理身分。山羊关节炎-脑炎（CAE）是由相同的病原体引起的；然而，仅在感染SRLV的山羊中偶尔报告了CIP的存在。我们进行了一项横断面研究，以确定有症状的CAE山羊中指示CIP的组织病理学病变的患病率。并调查CIP是否与其他类型肺炎(化脓性支气管肺炎，纤维性胸膜肺炎）或细菌感染。收集肺标本和支气管拭子进行组织病理学和细菌学检查，分别,来自受CAE影响的牛群的116只山羊。由于CAE的严重临床体征,所有山羊均被安乐死。在两种不同的ELISA中，山羊的SRLV感染呈血清阳性，并且通过免疫组织化学证实了肺组织中SRLV抗原的存在。组织病理学,82只山羊(70.7%)确诊了任何类型的肺炎,67只山羊(57.8%)出现CIP.在大多数山羊中，肺炎的组织病理学特征的严重程度为轻度。在73只山羊的支气管拭子中检测到细菌（62.9％）。CIP与化脓性支气管肺炎的发生呈显著正相关(p<0.001),纤维性胸膜肺炎（p=0.001），以及能够引起肺炎的细菌对肺部的感染（p=0.050）。应考虑这些关联的因果关系，并值得进一步调查。
