Abstract：
Background and Objectives: To estimate the association between admission functional outcomes and exposure to physiotherapy interventions with mortality rate in intensive care unit (ICU) inpatients with cardiovascular diseases and new coronavirus disease (COVID-19). Materials and Methods: Retrospective cohort including 100 ICU inpatients (mean (standard deviation), age 75 (16) years) split into COVID-19+ or COVID-19−. The association of in-ICU death with admission functional outcomes and physiotherapy interventions was investigated using univariable and multivariable regression models. Results: In total, 42 (42%) patients tested positive for COVID-19. In-ICU mortality rate was 37%, being higher for the COVID-19+ group (odds ratio, OR (95% CI): 3.15 (1.37−7.47), p = 0.008). In-ICU death was associated with lower admission ICU Mobility Scale score (0.81 (0.71−0.91), p = 0.001). Restricted mobility (24.90 (6.77−161.94), p < 0.001) and passive kinesiotherapy (30.67 (9.49−139.52), p < 0.001) were associated with in-ICU death, whereas active kinesiotherapy (0.13 (0.05−0.32), p < 0.001), standing (0.12 (0.05−0.30), p < 0.001), or walking (0.10 (0.03−0.27), p < 0.001) were associated with in-ICU discharge. Conclusions: In-ICU mortality was higher for inpatients with cardiovascular diseases who had COVID-19+, were exposed to invasive mechanical ventilation, or presented with low admission mobility scores. Restricted mobility or passive kinesiotherapy were associated with in-ICU death, whereas active mobilizations (kinesiotherapy, standing, or walking) were associated with in-ICU discharge in this population.
摘要：
背景和目的：评估重症监护病房（ICU）心血管疾病和新型冠状病毒病（COVID-19）患者入院功能结局和物理治疗干预措施暴露与死亡率之间的关系。材料和方法：回顾性队列，包括100名ICU住院患者(平均值(标准差)，75（16）岁）分为COVID-19+或COVID-19−。使用单变量和多变量回归模型研究了ICU内死亡与入院功能结局和物理治疗干预的关系。结果：总的来说，42例（42%）患者COVID-19检测呈阳性。ICU死亡率为37%,COVID-19+组更高(赔率比，OR（95%CI）：3.15（1.37−7.47），p=0.008)。ICU内死亡与较低的入院ICU流动性量表评分相关(0.81(0.71-0.91)，p=0.001)。行动受限(24.90(6.77−161.94)，p<0.001)和被动运动疗法(30.67(9.49−139.52)，p<0.001)与ICU内死亡相关，而积极运动疗法(0.13(0.05−0.32)，p<0.001)，站立(0.12(0.05−0.30)，p<0.001)，或步行(0.10(0.03−0.27)，p<0.001）与ICU出院相关。结论：患有COVID-19+的心血管疾病住院患者在ICU的死亡率更高，暴露于有创机械通气，或以低入学流动性分数呈现。活动受限或被动运动疗法与ICU内死亡相关，而主动动员(运动疗法，站立,或步行）与该人群的ICU出院有关。
