PDF(Pubmed)
Abstract：
Multiple myeloma is a disorder of the monoclonal plasma cells and is the second most common hematologic malignancy. Despite improvements in survival with newer treatment regimens, multiple myeloma remains an incurable disease and most patients experience multiple relapses. Multiple myeloma disease initiation and progression are highly dependent on complex genetic aberrations. This review will summarize the current knowledge of these genetic aberrations, how they affect prognosis and the response to treatment, and review sensitive molecular techniques for multiple myeloma workup, with the ultimate goal of detecting myeloma progression early, allowing for timely treatment initiation.
摘要：
多发性骨髓瘤是单克隆浆细胞的病症,并且是第二常见的血液系统恶性肿瘤。尽管新的治疗方案提高了生存率，多发性骨髓瘤仍然是一种无法治愈的疾病,大多数患者经历多次复发.多发性骨髓瘤疾病的发生和进展高度依赖于复杂的遗传畸变。这篇综述将总结这些遗传畸变的当前知识，它们如何影响预后和对治疗的反应，并回顾多发性骨髓瘤检查的敏感分子技术，最终目标是早期检测骨髓瘤的进展，允许及时开始治疗。
