关键词: NMR spectroscopy differential diagnosis myoinositol pineal neoplasms

来  源:   DOI:10.3390/brainsci12060802

Abstract:
Papillary tumor of the pineal region (PTPR) is an uncommon entity in which a presurgical suspicion may be crucial for patient management. Maximal safe neurosurgical resection is of choice when PTPR is suspected, whereas non-surgical approaches can be considered in other tumors of the pineal region, such as pineocytoma or concrete subtypes of germ-cell tumors. In general terms, imaging features of tumors of the pineal region have been reported to be unspecific. Nevertheless, in this report, we describe two pathology-confirmed PTPRs in which presurgical proton MR spectroscopy demonstrated extremely high myoinositol, a pattern which drastically differs from that of other pineal tumors. We hypothesize that this high myoinositol may be related to PTPR\'s known ependymal component, and that it could be used as a specific non-invasive diagnostic signature.
摘要:
松果体区乳头状肿瘤(PTPR)是一种罕见的实体,其中术前怀疑可能对患者管理至关重要。当怀疑PTPR时,最安全的神经外科切除术是首选,而在松果体区的其他肿瘤中可以考虑非手术方法,如松果细胞瘤或生殖细胞肿瘤的具体亚型。总的来说,据报道,松果体区肿瘤的影像学特征没有特异性。然而,在这份报告中,我们描述了两种病理证实的PTPR,其中术前质子MR波谱显示极高的肌醇,一种与其他松果体肿瘤截然不同的模式。我们假设这种高肌醇可能与PTPR的已知室管膜成分有关,并且它可以用作特定的非侵入性诊断标志。
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