Abstract：
BACKGROUND: Human Papilloma Virus (HPV) represents the most prevalent genital infection in young women of reproductive age.
OBJECTIVE: This systematic review aims to estimate the effect of HPV infection during pregnancy and assess the correlation between HPV and adverse pregnancy outcomes.
METHODS: The search strategy has been developed based on the PICOS framework: Population (pregnant women infected with HPV), Intervention (HPV infection confirmed by molecular tests), Comparator (pregnant women without HPV infection), Outcomes (adverse pregnancy outcomes) and Study design (observational studies). We searched PubMed, Web of Science, and Scopus databases on 8 January 2022 by using the following keywords: \"HPV\", \"prematurity\", \"preterm birth\", \"miscarriage\", \"premature rupture of membranes\", \"adverse pregnancy outcome\", \"low birth weight\", \"fetal growth restriction\", \"pregnancy-induced hypertensive disorders\", \"preeclampsia\". Selection criteria were HPV infection confirmed within maximum 2 years before pregnancy with a molecular test and adverse pregnancy outcomes. (Results: Although numerous studies are conducted on this topic, data are still controversial regarding identifying maternal HPV infection as a risk factor for adverse pregnancy outcomes. More prospective large cohort studies are needed to prove a causative relationship.
OBJECTIVE: This systematic review aims to estimate the effect of HPV infection during pregnancy and assess the correlation between HPV and adverse pregnancy outcomes.
METHODS: The search strategy has been developed based on the PICOS framework: Population (pregnant women infected with HPV), Intervention (HPV infection confirmed by molecular tests), Comparator (pregnant women without HPV infection), Outcomes (adverse pregnancy outcomes) and Study design (observational studies). We searched PubMed, Web of Science, and Scopus databases on 8 January 2022 by using the following keywords: \"HPV\", \"prematurity\", \"preterm birth\", \"miscarriage\", \"premature rupture of membranes\", \"adverse pregnancy outcome\", \"low birth weight\", \"fetal growth restriction\", \"pregnancy-induced hypertensive disorders\", \"preeclampsia\". Selection criteria were HPV infection confirmed within maximum 2 years before pregnancy with a molecular test and adverse pregnancy outcomes. (Results: Although numerous studies are conducted on this topic, data are still controversial regarding identifying maternal HPV infection as a risk factor for adverse pregnancy outcomes. More prospective large cohort studies are needed to prove a causative relationship.
摘要：
背景：人乳头瘤病毒（HPV）是育龄年轻女性中最常见的生殖器感染。
目的：本系统综述旨在评估妊娠期HPV感染的影响，并评估HPV与不良妊娠结局之间的相关性。
方法：搜索策略是基于PICOS框架开发的：人群（感染HPV的孕妇），干预（通过分子检测证实的HPV感染），比较（无HPV感染的孕妇），结果（不良妊娠结局）和研究设计（观察性研究）。我们搜索了PubMed,WebofScience,和Scopus数据库在2022年1月8日使用以下关键字：“HPV”，\"早产\",\"早产\",\"流产\",“胎膜早破”，“不良妊娠结局”，“低出生体重”，“胎儿生长受限”，“妊娠高血压疾病”，\"先兆子痫\"。选择标准是在妊娠前2年内确认HPV感染，并进行分子检测和不良妊娠结局。（结果：尽管对此主题进行了大量研究，关于将母体HPV感染确定为不良妊娠结局的危险因素的数据仍存在争议.需要更多的前瞻性大型队列研究来证明因果关系。
目的：本系统综述旨在评估妊娠期HPV感染的影响，并评估HPV与不良妊娠结局之间的相关性。
方法：搜索策略是基于PICOS框架开发的：人群（感染HPV的孕妇），干预（通过分子检测证实的HPV感染），比较（无HPV感染的孕妇），结果（不良妊娠结局）和研究设计（观察性研究）。我们搜索了PubMed,WebofScience,和Scopus数据库在2022年1月8日使用以下关键字：“HPV”，\"早产\",\"早产\",\"流产\",“胎膜早破”，“不良妊娠结局”，“低出生体重”，“胎儿生长受限”，“妊娠高血压疾病”，\"先兆子痫\"。选择标准是在妊娠前2年内确认HPV感染，并进行分子检测和不良妊娠结局。（结果：尽管对此主题进行了大量研究，关于将母体HPV感染确定为不良妊娠结局的危险因素的数据仍存在争议.需要更多的前瞻性大型队列研究来证明因果关系。
