Abstract：
A novel bacteria-based drug delivery system, termed \"Trojan nanobacteria system\", has been developed in which nanoagents are internalized into engineered bacteria through bacteria-specific maltodextrin (MD) transporters. Compared to the method of attaching nanoagents to bacterial surfaces, this Trojan system features higher payloads and better stability. In cancer therapy, Trojan nanobacteria can specifically discriminate the tumor region and then penetrate deep tumor tissues. Once in the tumor, the Trojan nanobacteria systems are able to destroy deep tumor tissues due to the combined effects of antitumor protein expression (e.g., tumor necrosis factor-α, TNF-α) and photothermal properties.
摘要：
一种新型的基于细菌的药物递送系统，称为“特洛伊木马纳米细菌系统”，已经开发了纳米试剂通过细菌特异性麦芽糊精（MD）转运蛋白内化到工程细菌中。与将纳米试剂附着到细菌表面的方法相比，此木马系统具有更高的有效载荷和更好的稳定性。在癌症治疗中，特洛伊木马纳米细菌可以特异性地辨别肿瘤区域，然后穿透深部肿瘤组织。一旦进入肿瘤，由于抗肿瘤蛋白表达的综合作用，特洛伊木马纳米细菌系统能够破坏深层肿瘤组织(例如，肿瘤坏死因子-α，TNF-α）和光热特性。
