Abstract：
Nonfunctioning pituitary neuroendocrine tumors (NF-PitNETs) are tumors that are not associated with clinical evidence of hormonal hypersecretion. According to the World Health Organization (WHO), there are some subtypes of PitNETs that exhibit more aggressive behavior than others. Among the types of potentially aggressive PitNETs, three are nonfunctional: silent sparsely granulated somatotropinomas, silent corticotropinomas, and poorly differentiated PIT-1 lineage tumors. Several biological markers have been investigated in NF-PitNETs. However, there is no single biomarker able to independently predict aggressive behavior in NF-PitNETs. Thus, a more complex and multidisciplinary proposal of a comprehensive definition of aggressive NF-PitNETs is necessary. Here, we suggest a combined and more complete criterion for the NF-PitNETs classification. We propose that aggressiveness is due to a multifactorial combination, and we emphasize the need to include new emerging markers that are involved in the aggressiveness of NF-PitNETs and the need to identify.
摘要：
无功能垂体神经内分泌肿瘤（NF-PitNETs）是与激素分泌过多的临床证据无关的肿瘤。根据世界卫生组织（WHO）PitNETs的一些亚型表现出比其他亚型更具攻击性的行为。在潜在的攻击性PitNET类型中，三种是无功能的：无症状的稀疏颗粒状生长激素瘤，沉默性促肾上腺皮质激素瘤,和低分化的PIT-1谱系肿瘤。已经在NF-PitNETs中研究了几种生物标记。然而,没有单一的生物标志物能够独立预测NF-PitNETs的攻击行为。因此，有必要提出更复杂和多学科的建议，全面定义积极的NF-PitNETs。这里,我们为NF-PitNETs分类提出了一个更完整的综合标准.我们认为侵略性是由于多因素的组合，我们强调需要包括新出现的标记，这些标记涉及NF-PitNETs的侵袭性和识别的必要性。
