Abstract：
Until now, in clinical dentistry, antibacterial photodynamic therapy (aPDT) has been restricted to in-office treatments, which hampers repeated applications. This pilot study tested the benefit of a commercially available Lumoral® device designed for regular periodontal dual-light aPDT treatment at home. Seven patients with peri-implant disease applied dual-light aPDT daily in addition to their normal dental hygiene for four weeks. A single Lumoral® treatment includes an indocyanine green mouth rinse followed by 40 J/cm2 radiant exposure to a combination of 810 nm and 405 nm light. A point-of-care analysis of active-matrix metalloproteinase (aMMP-8), visible plaque index (VPI), bleeding on probing (BOP), and peri-implant pocket depth (PPD) measurements was performed on day 0, day 15, and day 30. Reductions in aMMP-8 (p = 0.047), VPI (p = 0.03), and BOP (p = 0.03) were observed, and PPD was measured as being 1 mm lower in the implant (p = ns). These results suggest a benefit of regular application of dual-light aPDT in peri-implantitis. Frequently repeated application can be a promising approach to diminishing the microbial burden and to lowering the tissue destructive proteolytic and inflammatory load around dental implants. Further studies in larger populations are warranted to show the long-term benefits.
摘要：
直到现在,在临床牙科，抗菌光动力疗法（aPDT）仅限于办公室治疗，这阻碍了重复应用。这项初步研究测试了市售Lumoral®设备的益处，该设备设计用于在家中进行常规牙周双光aPDT治疗。7名种植体周围疾病患者除了正常的口腔卫生外，每天还应用双光aPDT，持续四周。单一Lumoral®处理包括吲哚菁绿漱口液,随后是40J/cm2辐射暴露于810nm和405nm光的组合。活性基质金属蛋白酶（aMMP-8）的即时分析，可见菌斑指数（VPI），探查出血(BOP),在第0天,第15天和第30天进行种植体周围袋深度(PPD)测量.aMMP-8的减少（p=0.047），VPI(p=0.03),观察到防喷器(p=0.03)，PPD在植入物中测量为低1mm(p=ns)。这些结果表明，在种植体周围炎中定期使用双光aPDT是有益的。经常重复施用可以是减少微生物负荷和降低牙科植入物周围的组织破坏性蛋白水解和炎症负荷的有希望的方法。有必要在更大的人群中进行进一步的研究，以显示长期的益处。
