PDF(Pubmed)
Abstract：
Heart failure (HF) remains the leading cause of death, morbidity, and medical expenses worldwide. Treatments for HF with reduced ejection fraction have progressed in recent years; however, acute decompensated heart failure remains difficult to treat. The transient receptor potential (TRP) channel family plays roles in various cardiovascular diseases, responding to neurohormonal and mechanical load stimulation. Thus, TRP channels are promising targets for drug discovery, and many studies have evaluated the roles of TRP channels expressed on pain neurons. The natriuretic peptide (NP) family of proteins regulates blood volume, natriuresis, and vasodilation and can antagonize the renin-angiotensin-aldosterone system and participate in the pathogenesis of major cardiovascular diseases, such as HF, coronary atherosclerotic heart disease, and left ventricular hypertrophy. NPs are degraded by neprilysin, and the blood level of NPs has predictive value in the diagnosis and prognostic stratification of HF. In this review, we discuss the relationships between typical TRP family channels (e.g., transient receptor potential cation channel subfamily V member 1 andTRPV1, transient receptor potential cation channel subfamily C member 6) and the NP system (e.g., atrial NP, B-type NP, and C-type NP) and their respective roles in HF. We also discuss novel drugs introduced for the treatment of HF.
摘要：
心力衰竭（HF）仍然是死亡的主要原因，发病率，全球医疗费用。近年来，降低射血分数的HF治疗取得了进展；然而，急性失代偿性心力衰竭仍然难以治疗。瞬时受体电位(TRP)通道家族在多种心血管疾病中发挥作用,响应神经激素和机械负荷刺激。因此，TRP通道是药物发现的有希望的目标，许多研究已经评估了在疼痛神经元上表达的TRP通道的作用。利钠肽（NP）家族蛋白调节血容量，利钠尿,能拮抗肾素-血管紧张素-醛固酮系统,比如HF,冠状动脉粥样硬化性心脏病,左心室肥厚.NPs被脑啡肽降解，血NPs水平对HF的诊断和预后分层具有预测价值。在这次审查中,我们讨论了典型的TRP家族频道之间的关系(例如，瞬时受体电位阳离子通道亚家族V成员1和TRPV1，瞬时受体电位阳离子通道亚家族C成员6）和NP系统（例如，心房NP,B型NP,和C型NP)及其在HF中的各自作用。我们还讨论了用于治疗HF的新药。
