PDF(Pubmed)
Abstract：
UNASSIGNED: Calcium sulphate is a recent alternative for delayed antibiotic elution in infected bones and joints. The purpose of this study is to evaluate the use of antibiotic impregnated calcium sulphate (AICS) beads in the management of infected tibia and femur, with regards to patient outcomes and complication rates (including reinfection rate, remission rate and union rate).
UNASSIGNED: Searches of AMED, CINAHL, EMBASE, EMCARE, Medline, PubMed and Google Scholar were conducted in June 2020, with the mesh terms: \"Calcium sulphate beads\" or \"Calcium sulfate beads\" or \"antibiotic beads\" or \"Stimulan\" AND \"Bone infection\" or \"Osteomyelitis\" or \"Debridement\" AND \"Tibia\" or \"Femur\". Risk of bias was assessed using the Risk of Bias in Non-randomised Studies of interventions (ROBINS-i) tool, and quality assessed via the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria.
UNASSIGNED: Out of 104 relevant papers, 10 met the inclusion criteria for data extraction. Total infection remission was 6.8%, which was greater than that of polymethylmethacrylate (PMMA, 21.2%). Complication rates varied. The main issue regarding AICS use was wound drainage, which was considerably higher in studies involving treatment of tibia alone. Studies using PMMA did not experience this issue, but there were a few incidences of superficial pin tract infection following surgery.
UNASSIGNED: Where AICS was used, it was consistently effective at infection eradication, despite variation in causative organism and location of bead placement. Wound drainage varied and was higher in papers regarding tibial cases alone.
UNASSIGNED: Searches of AMED, CINAHL, EMBASE, EMCARE, Medline, PubMed and Google Scholar were conducted in June 2020, with the mesh terms: \"Calcium sulphate beads\" or \"Calcium sulfate beads\" or \"antibiotic beads\" or \"Stimulan\" AND \"Bone infection\" or \"Osteomyelitis\" or \"Debridement\" AND \"Tibia\" or \"Femur\". Risk of bias was assessed using the Risk of Bias in Non-randomised Studies of interventions (ROBINS-i) tool, and quality assessed via the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria.
UNASSIGNED: Out of 104 relevant papers, 10 met the inclusion criteria for data extraction. Total infection remission was 6.8%, which was greater than that of polymethylmethacrylate (PMMA, 21.2%). Complication rates varied. The main issue regarding AICS use was wound drainage, which was considerably higher in studies involving treatment of tibia alone. Studies using PMMA did not experience this issue, but there were a few incidences of superficial pin tract infection following surgery.
UNASSIGNED: Where AICS was used, it was consistently effective at infection eradication, despite variation in causative organism and location of bead placement. Wound drainage varied and was higher in papers regarding tibial cases alone.
摘要：
■硫酸钙是最近在感染的骨骼和关节中延迟抗生素洗脱的替代品。这项研究的目的是评估在感染的胫骨和股骨的管理中使用抗生素浸渍的硫酸钙（AICS）珠，关于患者预后和并发症发生率(包括再感染率，缓解率和愈合率)。
■AMED的搜索，CINAHL,EMBASE,EMCARE,Medline,PubMed和GoogleScholar于2020年6月进行，使用网状术语：“硫酸钙珠”或“硫酸钙珠”或“抗生素珠”或“刺激”和“骨感染”或“骨髓炎”或“清创”和“胫骨”或“股骨”。使用非随机干预研究中的偏倚风险（ROBINS-i）工具评估偏倚风险，并通过建议分级评估质量，评估,开发和评估（等级）标准。
■在104篇相关论文中，10符合数据提取的纳入标准。总感染缓解率为6.8%,大于聚甲基丙烯酸甲酯(PMMA，21.2%）。并发症发生率各不相同。关于AICS使用的主要问题是伤口引流，在涉及单独治疗胫骨的研究中，这一比例要高得多。使用PMMA的研究没有遇到这个问题，但是手术后有一些浅表针道感染的发生率。
■在使用AICS的地方，它在根除感染方面一直有效，尽管致病生物和珠子放置位置不同。伤口引流各不相同，仅在胫骨病例中就更高。
■AMED的搜索，CINAHL,EMBASE,EMCARE,Medline,PubMed和GoogleScholar于2020年6月进行，使用网状术语：“硫酸钙珠”或“硫酸钙珠”或“抗生素珠”或“刺激”和“骨感染”或“骨髓炎”或“清创”和“胫骨”或“股骨”。使用非随机干预研究中的偏倚风险（ROBINS-i）工具评估偏倚风险，并通过建议分级评估质量，评估,开发和评估（等级）标准。
■在104篇相关论文中，10符合数据提取的纳入标准。总感染缓解率为6.8%,大于聚甲基丙烯酸甲酯(PMMA，21.2%）。并发症发生率各不相同。关于AICS使用的主要问题是伤口引流，在涉及单独治疗胫骨的研究中，这一比例要高得多。使用PMMA的研究没有遇到这个问题，但是手术后有一些浅表针道感染的发生率。
■在使用AICS的地方，它在根除感染方面一直有效，尽管致病生物和珠子放置位置不同。伤口引流各不相同，仅在胫骨病例中就更高。
