关键词: DIF, direct immunofluorescence EULAR, European Alliance of Associations for Rheumatology GI, gastrointestinal IgA vasculitis IgAV, IgA vasculitis IgAV-N, IgA vasculitis nephropathy LCV, leukocytoclastic vasculitis PRES, Pediatric Rheumatology European Society PRINTO, Pediatric Rheumatology International Trials Organization autoimmune dermatopathology direct immunofluorescence leukocytoclastic vasculitis vasculitis

来  源:   DOI:10.1016/j.jdin.2022.05.004   PDF(Pubmed)

Abstract:
UNASSIGNED: IgA vasculitis in adults has not been thoroughly studied. This has left a practice gap related to the management and follow-up of a population that is at an increased risk of comorbidities and potentially poor outcomes. For this reason, it is important to synthesize evidence from the current literature because this can help direct the movement for more robust studies to clarify best practice recommendations.
UNASSIGNED: We sought to create a narrative review for the practicing dermatologist when diagnosing and leading the care of IgA vasculitis in adult patients.
UNASSIGNED: A broad literature search was performed with a focus on articles that were published after the introduction of the most updated European Alliance of Associations for Rheumatology/Pediatric Rheumatology International Trials Organization/Pediatric Rheumatology European Society criteria.
UNASSIGNED: The characteristics and management guidelines for IgA vasculitis in adults have been refined, although more rigorous studies are needed to develop best practice recommendations.
UNASSIGNED: Because of the lack of sufficient randomized controlled trials on IgA vasculitis in adults, this narrative review is composed of mostly observational, descriptive studies.
UNASSIGNED: Adults with IgA vasculitis are at an increased risk of complicated disease course, necessitating formal diagnostic assessment and clear-cut follow-up recommendations to manage and prevent poor health outcomes related to various comorbidities.
摘要:
成人IgA血管炎尚未得到彻底研究。这在管理和随访人群方面留下了一个实践差距,这些人群的合并症和潜在的不良结果风险增加。出于这个原因,从目前的文献中综合证据是很重要的,因为这可以帮助指导更有力的研究运动,以阐明最佳实践建议.
在诊断和领导成人患者IgA血管炎时,我们试图为执业皮肤科医生创建一个叙述性综述。
进行了广泛的文献检索,重点是在推出最新欧洲风湿病学协会联盟/儿科风湿病学国际试验组织/儿科风湿病学欧洲协会标准后发表的文章。
完善了成人IgA血管炎的特点和治疗指南,尽管需要更严格的研究来制定最佳实践建议。
由于缺乏关于成人IgA血管炎的足够的随机对照试验,这篇叙事评论主要由观察性的,描述性研究。
患有IgA血管炎的成年人患复杂疾病的风险增加,需要正式的诊断评估和明确的后续建议,以管理和预防与各种合并症相关的不良健康结果。
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