Abstract：
Sepsis is a common, life-threatening syndrome of physiologic, pathologic, and biochemical abnormalities that are caused by infection and propagated by a dysregulated immune response. In 2017, the estimated annual incidence of sepsis around the world was 508 cases per 100,000 (95% confidence interval [CI], 422-612 cases per 100,000), however, reported incidence rates vary significantly by country. A scoping review will identify knowledge gaps by systematically investigating the incidence of sepsis.
This scoping review will be guided by the updated JBI (formerly Joanna Briggs Institute) methodology. We will search the following electronic databases: MEDLINE, EMBASE, CINAHL, and Cochrane Database of Systematic Reviews/Central Register of Controlled Trials. In addition, we will search websites of trial and study registries. We will review titles and abstracts of potentially eligible studies and then full-texts by two independent reviewers. We will include any study that is focused on the incidence of sepsis or septic shock in any population. Data will be abstracted independently using pre-piloted data extraction forms, and we will present results according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols Extension for Scoping Reviews.
The results of this review will be used to create a publicly available indexed and searchable electronic registry of existing sepsis research relating to incidence in neonates, children, and adults. With input from stakeholders, we will identify the implications of study findings for policy, practice, and research. Ethics approval was not required given this study reports on existing literature.
This scoping review will be guided by the updated JBI (formerly Joanna Briggs Institute) methodology. We will search the following electronic databases: MEDLINE, EMBASE, CINAHL, and Cochrane Database of Systematic Reviews/Central Register of Controlled Trials. In addition, we will search websites of trial and study registries. We will review titles and abstracts of potentially eligible studies and then full-texts by two independent reviewers. We will include any study that is focused on the incidence of sepsis or septic shock in any population. Data will be abstracted independently using pre-piloted data extraction forms, and we will present results according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols Extension for Scoping Reviews.
The results of this review will be used to create a publicly available indexed and searchable electronic registry of existing sepsis research relating to incidence in neonates, children, and adults. With input from stakeholders, we will identify the implications of study findings for policy, practice, and research. Ethics approval was not required given this study reports on existing literature.
摘要：
脓毒症是常见的,威胁生命的生理综合征，病理性,以及由感染引起并通过失调的免疫反应传播的生化异常。2017年，全球脓毒症的估计年发病率为每10万人508例(95%置信区间[CI]，422-612例/100,000)，然而,报告的发病率因国家而异。范围审查将通过系统地调查脓毒症的发病率来确定知识差距。
此范围审查将以更新的JBI（以前的JoannaBriggsInstitute）方法为指导。我们将搜索以下电子数据库:MEDLINE,EMBASE,CINAHL,和Cochrane系统审查数据库/对照试验中央登记册。此外,我们将搜索试验和研究注册网站。我们将审查标题和潜在的合格研究的摘要，然后由两名独立审稿人的全文。我们将包括任何针对任何人群中败血症或败血症性休克发生率的研究。数据将使用预试点数据提取表格独立提取，我们将根据系统审查的首选报告项目和范围审查的荟萃分析方案扩展提供结果。
本综述的结果将用于创建与新生儿发病率有关的现有败血症研究的公开索引和可搜索的电子注册表，孩子们,和成年人。有了利益相关者的投入，我们将确定研究结果对政策的影响，实践,和研究。鉴于本研究报告现有文献，不需要伦理批准。
此范围审查将以更新的JBI（以前的JoannaBriggsInstitute）方法为指导。我们将搜索以下电子数据库:MEDLINE,EMBASE,CINAHL,和Cochrane系统审查数据库/对照试验中央登记册。此外,我们将搜索试验和研究注册网站。我们将审查标题和潜在的合格研究的摘要，然后由两名独立审稿人的全文。我们将包括任何针对任何人群中败血症或败血症性休克发生率的研究。数据将使用预试点数据提取表格独立提取，我们将根据系统审查的首选报告项目和范围审查的荟萃分析方案扩展提供结果。
本综述的结果将用于创建与新生儿发病率有关的现有败血症研究的公开索引和可搜索的电子注册表，孩子们,和成年人。有了利益相关者的投入，我们将确定研究结果对政策的影响，实践,和研究。鉴于本研究报告现有文献，不需要伦理批准。
