METHODS: An electronic search was performed in PubMed/Medline, Web of Science, Science Direct, Scopus, Embase, and the Cochrane Collaboration Library. Publications assessing the relationship between TSR and prognosis in cases of HNSCC were eligible. The quality of the studies was assessed independently by four evaluators using the Newcastle-Ottawa scale.
RESULTS: After application of the previously es+lished inclusion/exclusion criteria, nine articles were included in the qualitative synthesis. With regards to quality on the Newcastle-Ottawa scale, an overall value of 4.55 was obtained. This systematic review demonstrated a strong association between TSR and prognosis in esophageal and oral squamous cell carcinomas.
CONCLUSIONS: Histopathological analysis of the TSR can optimize the analysis of the prognosis of cases diagnosed with HNSSC. In addition, the TSR is a reliable and simple parameter that can be evaluated in hematoxylin/eosin-stained slides during routine laboratory examinations, showing high inter- and intraobserver agreement.
方法:在PubMed/Medline中进行了电子搜索,WebofScience,科学直接,Scopus,Embase,和Cochrane合作图书馆.评估HNSCC病例中TSR与预后之间关系的出版物符合资格。研究的质量由四名评估者使用纽卡斯尔-渥太华量表独立评估。
结果:在应用先前已确定的纳入/排除标准后,9篇文章被纳入定性综合。关于纽卡斯尔-渥太华规模的质量,获得的总价值为4.55。这项系统评价表明,食管和口腔鳞状细胞癌的TSR与预后之间存在很强的相关性。
结论:TSR的组织病理学分析可以优化HNSSC诊断病例的预后分析。此外,TSR是一个可靠且简单的参数,可以在常规实验室检查期间在苏木精/伊红染色的载玻片中进行评估,显示出观察者之间和观察者内部的高度一致性。