METHODS: 18F-FDG PET/CT images were available for MTV and TLG analysis in 107 cases from the HD16 trial. We calculated MTV and TLG using three different threshold methods (SUV4.0, SUV41% and SUV140%L), and then performed receiver-operating-characteristic analysis to assess the predictive impact of these parameters in predicting an adequate therapy response with PET negativity after 2 cycles of chemotherapy.
RESULTS: All three threshold methods analyzed for MTV and TLG calculation showed a positive correlation with the PET response after 2 cycles chemotherapy. The largest area under the curve (AUC) was observed using the fixed threshold of SUV4.0 for MTV- calculation (AUC 0.69 [95% CI 0.55-0.83]) and for TLG-calculation (AUC 0.69 [0.55-0.82]). The calculations for MTV and TLG with a relative threshold showed a lower AUC: using SUV140%L AUCs of 0.66 [0.53-0.80] for MTV and 0.67 for TLG [0.54-0.81]) were observed, while with SUV41% an AUC of 0.61 [0.45-0.76] for MTV, and an AUC 0.64 [0.49-0.80]) for TLG were seen.
CONCLUSIONS: MTV and TLG do have a predictive value after two cycles ABVD in early stage Hodgkin lymphoma, particularly when using the fixed threshold of SUV4.0 for MTV and TLG calculation.
BACKGROUND: ClinicalTrials.gov NCT00736320 .
方法:18F-FDGPET/CT图像可用于HD16试验的107例患者的MTV和TLG分析。我们使用三种不同的阈值方法(SUV4.0、SUV41%和SUV140%L)计算了MTV和TLG,然后进行接受者操作特征分析,以评估这些参数在预测2个周期化疗后PET阴性的适当治疗反应方面的预测影响。
结果:分析MTV和TLG计算的所有三种阈值方法均显示与2周期化疗后的PET反应呈正相关。使用SUV4.0的固定阈值进行MTV-计算(AUC0.69[95%CI0.55-0.83])和TLG-计算(AUC0.69[0.55-0.82])观察到最大的曲线下面积(AUC)。对于具有相对阈值的MTV和TLG的计算显示了较低的AUC:对于MTV使用0.66[0.53-0.80]的SUV140%LAUC,对于TLG使用0.67[0.54-0.81])。而SUV41%的MTV的AUC为0.61[0.45-0.76],并且观察到TLG的AUC为0.64[0.49-0.80])。
结论:MTV和TLG在早期霍奇金淋巴瘤中两个周期ABVD后确实具有预测价值,特别是在使用SUV4.0的固定阈值进行MTV和TLG计算时。
背景:ClinicalTrials.govNCT00736320。