PDF(Pubmed)
Abstract：
UNASSIGNED: Nutrition is an essential factor in preventing and managing bronchopulmonary dysplasia (BPD), a multifactorial chronic respiratory disease in premature infants. This study examined the association between nutritional intakes during the first 2 weeks of life and BPD in extremely preterm infants.
UNASSIGNED: A retrospective single-center cohort study was performed in infants born <28 weeks\' gestational age or with a birth weight <1,000 g. Intake of energy and ratio of enteral feeding/ total fluid intake during the first 2 weeks of life and association with outcome of BPD were examined.
UNASSIGNED: 134 infants were included in our study, and 43 infants (32.1%) developed BPD. During the first 2 weeks of life, the average of total caloric intake and the ratio of enteral feeding/ total fluid intake were significantly lower in the BPD group (total caloric intake:91.90 vs. 95.72 kcal/kg/d, p < 0.05, ratio of enteral feeding/total fluid intake: 0.14 vs. 0.18, p < 0.05), while the average of total fluid intake, caloric and protein intake from parenteral nutrition did not differ between the groups. The ratio of enteral feeding/ total fluid intake during the second week were significantly lower in the BPD group (0.21 vs. 0.28, p < 0.05), while this ratio during the first week did not differ between the groups. An increase of 10% in the ratio of enteral feeding/ total fluid intake during the second week of life significantly reduced the risk of BPD (OR 0.444, 95% CI: 0.270-0.731).
UNASSIGNED: A higher ratio of enteral feeding/ total fluid intake was associated with a lower risk for BPD. Early and rapidly progressive enteral nutrition should be encouraged in extremely preterm infants in the absence of feeding intolerance.
UNASSIGNED: A retrospective single-center cohort study was performed in infants born <28 weeks\' gestational age or with a birth weight <1,000 g. Intake of energy and ratio of enteral feeding/ total fluid intake during the first 2 weeks of life and association with outcome of BPD were examined.
UNASSIGNED: 134 infants were included in our study, and 43 infants (32.1%) developed BPD. During the first 2 weeks of life, the average of total caloric intake and the ratio of enteral feeding/ total fluid intake were significantly lower in the BPD group (total caloric intake:91.90 vs. 95.72 kcal/kg/d, p < 0.05, ratio of enteral feeding/total fluid intake: 0.14 vs. 0.18, p < 0.05), while the average of total fluid intake, caloric and protein intake from parenteral nutrition did not differ between the groups. The ratio of enteral feeding/ total fluid intake during the second week were significantly lower in the BPD group (0.21 vs. 0.28, p < 0.05), while this ratio during the first week did not differ between the groups. An increase of 10% in the ratio of enteral feeding/ total fluid intake during the second week of life significantly reduced the risk of BPD (OR 0.444, 95% CI: 0.270-0.731).
UNASSIGNED: A higher ratio of enteral feeding/ total fluid intake was associated with a lower risk for BPD. Early and rapidly progressive enteral nutrition should be encouraged in extremely preterm infants in the absence of feeding intolerance.
摘要：
■营养是预防和管理支气管肺发育不良（BPD）的重要因素，早产儿的多因素慢性呼吸道疾病。这项研究检查了极端早产儿在生命的前2周内的营养摄入量与BPD之间的关系。
■在胎龄<28周或出生体重<1,000g的婴儿中进行了一项回顾性单中心队列研究。检查了生命最初2周内的能量摄入和肠内喂养/总液体摄入量的比率以及与BPD结局的关系。
■134名婴儿被纳入我们的研究，43例(32.1%)婴儿发生BPD。在生命的前两周，在BPD组中，总热量摄入的平均值和肠内喂养/总液体摄入的比率显着降低（总热量摄入：91.90vs.95.72kcal/kg/d,p<0.05，肠内喂养/总液体摄入量之比：0.14vs.0.18，p<0.05)，而总液体摄入量的平均值，来自肠外营养的热量和蛋白质摄入量在两组之间没有差异。在BPD组中，第二周的肠内喂养/总液体摄入量的比率显着降低（0.21vs.0.28，p<0.05)，而第一周的这一比率在组间没有差异。在生命的第二周内，肠内喂养/总液体摄入量的比例增加10％可显着降低BPD的风险（OR0.444，95％CI：0.270-0.731）。
■较高的肠内喂养/总液体摄入量与较低的BPD风险相关。在没有喂养不耐受的极端早产儿中，应鼓励早期和快速进行的肠内营养。
■在胎龄<28周或出生体重<1,000g的婴儿中进行了一项回顾性单中心队列研究。检查了生命最初2周内的能量摄入和肠内喂养/总液体摄入量的比率以及与BPD结局的关系。
■134名婴儿被纳入我们的研究，43例(32.1%)婴儿发生BPD。在生命的前两周，在BPD组中，总热量摄入的平均值和肠内喂养/总液体摄入的比率显着降低（总热量摄入：91.90vs.95.72kcal/kg/d,p<0.05，肠内喂养/总液体摄入量之比：0.14vs.0.18，p<0.05)，而总液体摄入量的平均值，来自肠外营养的热量和蛋白质摄入量在两组之间没有差异。在BPD组中，第二周的肠内喂养/总液体摄入量的比率显着降低（0.21vs.0.28，p<0.05)，而第一周的这一比率在组间没有差异。在生命的第二周内，肠内喂养/总液体摄入量的比例增加10％可显着降低BPD的风险（OR0.444，95％CI：0.270-0.731）。
■较高的肠内喂养/总液体摄入量与较低的BPD风险相关。在没有喂养不耐受的极端早产儿中，应鼓励早期和快速进行的肠内营养。
