Abstract：
BACKGROUND: Elevated platelet count (PC), mean platelet volume (MPV), and Platelet Mass Index (PMI) are reported in patients with psoriasis, while platelet activation is associated with psoriasis severity. Available studies examining the relationship between platelet activation markers and psoriasis have mostly focused on psoriasis area severity index. To the best of our knowledge, there is no study examining the relationship between histopathological features of a single psoriatic plaque and platelet activation. The present study examined the relationship between histomorphological findings obtained by morphometric analysis and psoriasis patients\' PC, MPV, and PMI values.
METHODS: Morphometric analysis was performed on hematoxylin and eosin-stained preparations of skin biopsies to measure minimum suprapapillary epidermis thickness (SPETmin ) and maximum epidermal thickness (ETmax ), maximum suprapapillary keratosis thickness (SPKTmax ), and maximum keratosis thickness (KTmax ). The relationship between PC, MPV, PMI, and morphometric skin biopsy outcomes was evaluated.
RESULTS: While an inverse correlation was found between SPETmin and PC and PMI in cases with psoriasis (p values = 0.015 and 0.005, r values = -0.238 and -0.271, respectively), no significant correlation was found between SPETmin and MPV (p value = 0.600, r value = -. 052). On the contrary, no significant correlation was found between SPKTmax, ETmax, and KTmax values and platelet parameters.
CONCLUSIONS: We assume that an increased risk of platelet activation-related diseases is expected in psoriasis patients displaying histopathological findings of suprapapillary thinning due to increased platelet activation; therefore, it may be beneficial to monitor these patients in terms of such risks.
METHODS: Morphometric analysis was performed on hematoxylin and eosin-stained preparations of skin biopsies to measure minimum suprapapillary epidermis thickness (SPETmin ) and maximum epidermal thickness (ETmax ), maximum suprapapillary keratosis thickness (SPKTmax ), and maximum keratosis thickness (KTmax ). The relationship between PC, MPV, PMI, and morphometric skin biopsy outcomes was evaluated.
RESULTS: While an inverse correlation was found between SPETmin and PC and PMI in cases with psoriasis (p values = 0.015 and 0.005, r values = -0.238 and -0.271, respectively), no significant correlation was found between SPETmin and MPV (p value = 0.600, r value = -. 052). On the contrary, no significant correlation was found between SPKTmax, ETmax, and KTmax values and platelet parameters.
CONCLUSIONS: We assume that an increased risk of platelet activation-related diseases is expected in psoriasis patients displaying histopathological findings of suprapapillary thinning due to increased platelet activation; therefore, it may be beneficial to monitor these patients in terms of such risks.
摘要：
背景：血小板计数（PC）升高，平均血小板体积（MPV），和血小板质量指数（PMI）报告在银屑病患者，而血小板活化与银屑病的严重程度有关。检查血小板活化标志物与银屑病之间关系的现有研究主要集中在银屑病面积严重程度指数上。据我们所知,没有研究检查单个银屑病斑块的组织病理学特征与血小板活化之间的关系。本研究检查了通过形态计量学分析获得的组织形态学结果与银屑病患者PC之间的关系，MPV,和PMI值。
方法：对皮肤活检的苏木精和曙红染色制剂进行形态测量分析，以测量最小毛细血管上表皮厚度（SPETmin）和最大表皮厚度（ETmax），最大乳头上角化厚度（SPKTmax），和最大角化厚度（KTmax）。PC之间的关系,MPV,PMI,并评估了形态测量皮肤活检结果.
结果：虽然在银屑病病例中发现SPETmin与PC和PMI呈负相关（p值分别为-0.015和0.005，r值分别为-0.238和-0.271），SPETmin和MPV之间没有发现显着相关性（p值=0.600，r值=-。052).相反,SPKTmax之间没有发现显著的相关性，ETmax,和KTmax值和血小板参数。
结论：我们认为，由于血小板活化增加，显示组织病理学发现的毛细血管上变薄的银屑病患者，预期血小板活化相关疾病的风险增加；因此，监测这些患者的此类风险可能是有益的。
方法：对皮肤活检的苏木精和曙红染色制剂进行形态测量分析，以测量最小毛细血管上表皮厚度（SPETmin）和最大表皮厚度（ETmax），最大乳头上角化厚度（SPKTmax），和最大角化厚度（KTmax）。PC之间的关系,MPV,PMI,并评估了形态测量皮肤活检结果.
结果：虽然在银屑病病例中发现SPETmin与PC和PMI呈负相关（p值分别为-0.015和0.005，r值分别为-0.238和-0.271），SPETmin和MPV之间没有发现显着相关性（p值=0.600，r值=-。052).相反,SPKTmax之间没有发现显著的相关性，ETmax,和KTmax值和血小板参数。
结论：我们认为，由于血小板活化增加，显示组织病理学发现的毛细血管上变薄的银屑病患者，预期血小板活化相关疾病的风险增加；因此，监测这些患者的此类风险可能是有益的。
