PDF(Pubmed)
Abstract：
Oleaginous fungi (including fungus-like protists) are attractive in lipid production due to their short growth cycle, large biomass and high yield of lipids. Some typical oleaginous fungi including Galactomyces geotrichum, Thraustochytrids, Mortierella isabellina, and Mucor circinelloides, have been well studied for the ability to accumulate fatty acids with commercial application. Here, we review recent progress toward fermentation, extraction, of fungal fatty acids. To reduce cost of the fatty acids, fatty acid productions from raw materials were also summarized. Then, the synthesis mechanism of fatty acids was introduced. We also review recent studies of the metabolic engineering strategies have been developed as efficient tools in oleaginous fungi to overcome the biochemical limit and to improve production efficiency of the special fatty acids. It also can be predictable that metabolic engineering can further enhance biosynthesis of fatty acids and change the storage mode of fatty acids.
摘要：
产油真菌（包括真菌样原生生物）由于其生长周期短，在脂质生产中具有吸引力，生物量大，脂质产量高。一些典型的含油真菌，包括地理发霉，Thraustochytrids,Isabellina被孢霉,和周围的Mucor，已经对商业应用中积累脂肪酸的能力进行了充分的研究。这里,我们回顾了发酵的最新进展，提取,真菌脂肪酸。为了降低脂肪酸的成本，还总结了原料脂肪酸的生产。然后，介绍了脂肪酸的合成机理。我们还回顾了最近对代谢工程策略的研究，这些策略已被开发为含油真菌的有效工具，以克服生化限制并提高特殊脂肪酸的生产效率。可以预见的是,代谢工程可以进一步增强脂肪酸的生物合成并改变脂肪酸的储存模式。
