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Abstract：
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β) family, are multifunctional cytokines. BMPs have a broad range of functions, and abnormalities in BMP signaling pathways are involved in cancer progression. BMPs activate the proliferation of certain cancer cells. Malignant phenotypes of cancer cells, such as increased motility, invasiveness, and stemness, are enhanced by BMPs. Simultaneously, BMPs act on various cellular components and regulate angiogenesis in the tumor microenvironment. Thus, BMPs function as pro-tumorigenic factors in various types of cancer. However, similar to TGF-β, which shows both positive and negative effects on tumorigenesis, BMPs also act as tumor suppressors in other types of cancers. In this article, we review important findings published in the recent decade and summarize the pro-oncogenic functions of BMPs and their underlying mechanisms. The current status of BMP-targeted therapies for cancers is also discussed.
摘要：
骨形态发生蛋白(BMPs),转化生长因子-β（TGF-β）家族的成员，是多功能细胞因子。BMP具有广泛的功能，BMP信号通路的异常与癌症进展有关。BMP激活某些癌细胞的增殖。癌细胞的恶性表型，例如增加的运动性，侵入性,和干劲，由BMP增强。同时,BMP作用于各种细胞成分并调节肿瘤微环境中的血管生成。因此，BMP在各种类型的癌症中充当促肿瘤发生因子。然而,与TGF-β相似，这显示了对肿瘤发生的积极和消极影响，BMP还在其他类型的癌症中充当肿瘤抑制因子。在这篇文章中,我们回顾了近十年发表的重要发现,并总结了BMP的致癌作用及其潜在机制.还讨论了针对癌症的BMP靶向疗法的现状。
