Abstract：
Invasive meningococcal disease (IMD) caused by Neisseria meningitidis (Nm) continues to be a global public health concern. Understanding the prevalence of Nm serogroups in IMD is critical for developing strategies for meningococcal vaccination. We used the keywords \"cerebrospinal meningitis\", \"meningococcal\", \"Neisseria meningitidis\'\', \"meningococcal meningitis\", \"serogroup\'\' and \"China\'\' to search five databases, including PubMed, CNKI, CBM (Chinese BioMedical Literature Database), WanFang and VIP from 2010 to 2020. The age distributions, proportions of Nm serogroups and serogroup changes in IMD were analyzed. A total of 14 studies were included according to PRISMA guidelines. In China, from 2010 to 2020, the highest proportion of Nm in IMD was NmC, with 49.7% (95% CI: 35.8%-63.5%), followed by NmB with 30.2% (95%CI:17.3%-43.0%) and NmW with 23.8% (95%CI: 7.0-40.7%). Before 2014, NmC was the major circulating serogroup, with 59.6% (95% CI: 43.8%-75.4%), followed by NmW with 24.4% (95% CI: 5.9%-42.9%). After 2015, IMD cases caused by NmB were increasing, the proportion of NmB reached to 52.4% (95% CI: 31.8%-73.1%). The age groups of children from 0 to 5 years and from 6 to 10 years represented, respectively, 29.6% (95% CI: 16.8%-42.4%) and 28.9% (95% CI: 12.1%-45.8%) of all IMD cases were reported. In China, NmB, NmC and NmW were the major serogroups causing IMD between 2010 and 2020. Since 2015, the proportion of NmB increased rapidly. The current serogroup distribution in China highlights the need of replacing the meningococcal polysaccharide vaccines that are being used in the National Immunization Program with more appropriate vaccines.
摘要：
由脑膜炎奈瑟菌（Nm）引起的侵袭性脑膜炎球菌病（IMD）仍然是全球公共卫生问题。了解IMD中Nm血清群的流行对于制定脑膜炎球菌疫苗接种策略至关重要。我们使用了关键词“脑脊髓膜炎”，\"脑膜炎球菌\",\"脑膜炎奈瑟菌\'\',\"脑膜炎球菌性脑膜炎\",“血清群”和“中国”搜索五个数据库，包括PubMed,CNKI,CBM(中国生物医学文献数据库),万方和VIP从2010年到2020年。年龄分布,分析了IMD中Nm血清群的比例和血清群的变化。根据PRISMA指南共纳入14项研究。在中国,从2010年到2020年，Nm在IMD中所占比例最高的是NmC，49.7%（95%CI：35.8%-63.5%），其次是NmB为30.2%(95CI:17.3%-43.0%)和NmW为23.8%(95CI:7.0-40.7%)。在2014年之前，NmC是主要的循环血清群，59.6%（95%CI：43.8%-75.4%），其次是NmW，占24.4%（95%CI：5.9%-42.9%）。2015年后，由NmB引起的IMD病例不断增加，NmB比例达到52.4%(95%CI:31.8%-73.1%)。0至5岁和6至10岁的儿童年龄组代表，分别,报告了所有IMD病例的29.6％（95％CI：16.8％-42.4％）和28.9％（95％CI：12.1％-45.8％）。在中国,NmB,NmC和NmW是2010年至2020年间导致IMD的主要血清群。2015年以来，NmB比例迅速上升。中国目前的血清群分布突出表明，需要用更合适的疫苗替代国家免疫计划中使用的脑膜炎球菌多糖疫苗。
