Abstract：
Phytochemical investigation of the methanol extracts from the leaves and bark of Senna siamea resulted in the isolation of one new flavone C-glycoside: apigenin-8-C-[6\'\'-(E)-feruloyl]-β-D-glucopyranoside] (1), together with sixteen known compounds including quercetin-3-O-α-L-rhamnoside (2), vitexin (3), isovitexin (4), quercetin-3-O-β-D-glucopyranoside (5), quercetin-3-O-β-D-arabinopyranoside (6), quercetin (7), kaempferol (8), methyl inositol (9), sucrose (10), betulinic acid (11), vanillic acid (12), stigmastane-3β,6α-diol (13), aurantiamide acetate (14), robinetinidol (15), catechin (16) and epicatechin (17). The structures of these compounds were established on the basis of their spectroscopic (1 D and 2 D NMR) and mass spectrometric (ESI-TOF-MS) data. The methanol extracts, fractions and some of the isolated compounds were screened for their antimicrobial properties against five microbial strains. The methanol extract and the ethyl acetate fraction from the bark showed very weak antifungal activity against C. glabrata with the same MIC value of 128 μg/mL. Compound 7 was weakly active against C. albicans with MIC of 32 μg/mL.
摘要：
对番泻叶叶和树皮中甲醇提取物的植物化学研究导致分离出一种新的黄酮C-糖苷：芹菜素-8-C-[6\'\'-（E）-阿魏酸]-β-D-吡喃葡萄糖苷]（1），连同16种已知化合物，包括槲皮素-3-O-α-L-鼠李糖苷（2），vitexin(3),异硫酸酯素(4),槲皮素-3-O-β-D-吡喃葡萄糖苷(5)，槲皮素-3-O-β-D-阿拉伯吡喃糖苷（6），槲皮素（7），山奈酚（8），甲基肌醇（9），蔗糖（10），桦木酸（11），香草酸(12),stigmastane-3β，6α-二醇(13)，auantiamide乙酸酯（14），robinetinidol(15),儿茶素（16）和表儿茶素（17）。这些化合物的结构基于其光谱(1D和2DNMR)和质谱(ESI-TOF-MS)数据来确定。甲醇提取物，筛选了部分和一些分离的化合物对五种微生物菌株的抗菌性能。来自树皮的甲醇提取物和乙酸乙酯级分显示出非常弱的抗光念珠菌活性,具有128μg/mL的相同MIC值。化合物7对白色念珠菌具有弱活性,MIC为32μg/mL。
