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Abstract：
UNASSIGNED: Psoriasis is a chronic dermatosis with potential to cause systemic disease by triggering dysmetabolism, such as metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). We studied the relationship and associations between NAFLD and clinical features, including age, gender, disease duration, and severity of psoriasis in our patients.
UNASSIGNED: This cross-sectional study comprised 61 (m:f, 43:19) patients without pre-existing comorbidities and matched 24 (m:f, 16:8) healthy controls aged between 20 and 68 years. Disease severity was graded as mild, moderate, and severe by psoriasis area and severity index score and body surface area (BSA) involvement. The grades of fatty liver and liver fibrosis were assessed using liver ultrasonography (USG) and transitional vibration-controlled elastography (Fibroscan).
UNASSIGNED: Overall, 67.2% of patients were aged >40 years, and the duration of disease was <5years in 60.7% of patients. Mild and moderate to severe psoriasis occurred in 78.7% and 21.3% of patients, respectively. BSA was >10% in 57.5% patients. The proportion of NAFLD was 27.9% and 32.8% by USG and Fibroscan compared with 20.8% in controls. Statistically, there was no significant difference or association between the prevalence of NAFLD among patients and controls, and gender, age (mean ± standard deviation, 47.5 ± 13.8 vs. 45.2 ± 15.7), duration, severity of psoriasis, and arthritis between psoriatic patients with and without NAFLD.
UNASSIGNED: This was a pilot study because of the numerosity of sample and highlights trends for possible link between psoriasis and NAFLD, but the results need cautious interpretation and clinical application. Whether NAFLD can be attributed to overall systemic inflammatory process of psoriasis or it occurs as an epiphenomenon of concurrent metabolic syndrome needs elucidation with well-designed studies. Cross-sectional study design, small number of patients, and controls remain major limitations. The study did not compare its findings with liver biopsy.
UNASSIGNED: This cross-sectional study comprised 61 (m:f, 43:19) patients without pre-existing comorbidities and matched 24 (m:f, 16:8) healthy controls aged between 20 and 68 years. Disease severity was graded as mild, moderate, and severe by psoriasis area and severity index score and body surface area (BSA) involvement. The grades of fatty liver and liver fibrosis were assessed using liver ultrasonography (USG) and transitional vibration-controlled elastography (Fibroscan).
UNASSIGNED: Overall, 67.2% of patients were aged >40 years, and the duration of disease was <5years in 60.7% of patients. Mild and moderate to severe psoriasis occurred in 78.7% and 21.3% of patients, respectively. BSA was >10% in 57.5% patients. The proportion of NAFLD was 27.9% and 32.8% by USG and Fibroscan compared with 20.8% in controls. Statistically, there was no significant difference or association between the prevalence of NAFLD among patients and controls, and gender, age (mean ± standard deviation, 47.5 ± 13.8 vs. 45.2 ± 15.7), duration, severity of psoriasis, and arthritis between psoriatic patients with and without NAFLD.
UNASSIGNED: This was a pilot study because of the numerosity of sample and highlights trends for possible link between psoriasis and NAFLD, but the results need cautious interpretation and clinical application. Whether NAFLD can be attributed to overall systemic inflammatory process of psoriasis or it occurs as an epiphenomenon of concurrent metabolic syndrome needs elucidation with well-designed studies. Cross-sectional study design, small number of patients, and controls remain major limitations. The study did not compare its findings with liver biopsy.
摘要：
牛皮癣是一种慢性皮肤病，有可能通过引发代谢异常而引起全身性疾病，如代谢综合征和非酒精性脂肪性肝病（NAFLD）。我们研究了NAFLD与临床特征之间的关系和关联，包括年龄,性别,疾病持续时间,以及我们患者牛皮癣的严重程度。
■这项横断面研究包括61（m：f，43：19）没有先前存在的合并症的患者和匹配的24（m：f，16：8）年龄在20至68岁之间的健康对照。疾病严重程度分级为轻度，中度,严重的是银屑病面积和严重程度指数评分以及体表面积（BSA）受累。使用肝脏超声检查（USG）和过渡性振动控制弹性成像（Fibroscan）评估脂肪肝和肝纤维化的等级。
■总的来说，67.2%的患者年龄>40岁,60.7%的患者病程<5年。轻度和中度至重度银屑病发生在78.7%和21.3%的患者中，分别。57.5%患者的BSA>10%。USG和Fibroscan的NAFLD比例分别为27.9%和32.8%，而对照组为20.8%。统计上,患者和对照组的NAFLD患病率之间没有显着差异或关联，和性别,年龄(平均值±标准偏差，47.5±13.8vs.45.2±15.7),持续时间,牛皮癣的严重程度，有和没有NAFLD的银屑病患者之间的关节炎。
■这是一项初步研究，因为样本数量众多，突出了牛皮癣和NAFLD之间可能联系的趋势，但结果需要谨慎解释和临床应用。NAFLD是否可以归因于银屑病的整体全身性炎症过程，还是作为并发代谢综合征的附带现象发生，需要精心设计的研究来阐明。横断面研究设计，少数患者，和控制仍然是主要的限制。该研究未将其发现与肝活检进行比较。
■这项横断面研究包括61（m：f，43：19）没有先前存在的合并症的患者和匹配的24（m：f，16：8）年龄在20至68岁之间的健康对照。疾病严重程度分级为轻度，中度,严重的是银屑病面积和严重程度指数评分以及体表面积（BSA）受累。使用肝脏超声检查（USG）和过渡性振动控制弹性成像（Fibroscan）评估脂肪肝和肝纤维化的等级。
■总的来说，67.2%的患者年龄>40岁,60.7%的患者病程<5年。轻度和中度至重度银屑病发生在78.7%和21.3%的患者中，分别。57.5%患者的BSA>10%。USG和Fibroscan的NAFLD比例分别为27.9%和32.8%，而对照组为20.8%。统计上,患者和对照组的NAFLD患病率之间没有显着差异或关联，和性别,年龄(平均值±标准偏差，47.5±13.8vs.45.2±15.7),持续时间,牛皮癣的严重程度，有和没有NAFLD的银屑病患者之间的关节炎。
■这是一项初步研究，因为样本数量众多，突出了牛皮癣和NAFLD之间可能联系的趋势，但结果需要谨慎解释和临床应用。NAFLD是否可以归因于银屑病的整体全身性炎症过程，还是作为并发代谢综合征的附带现象发生，需要精心设计的研究来阐明。横断面研究设计，少数患者，和控制仍然是主要的限制。该研究未将其发现与肝活检进行比较。
