Abstract：
Blueberries are known for their high content of several bioactive compounds, specifically anthocyanin, which are the most beneficial of the flavonoid family in terms of neuroprotection. Several human interventional studies have been conducted to assess the effects of blueberry intake on cognitive performance; however, the results of clinical trials are inconclusive. Therefore, this systematic review and meta-analysis evaluated the effect of blueberry supplementation on some aspects of cognitive performance and mood parameters using data from clinical trials based on existing evidence.
Relevant studies, published in April 2021, were searched through PubMed/Medline, Scopus, Embase, and Google Scholar. The random effect size was used to estimate the pooled effect size. Heterogeneity between studies was evaluated by the Cochrane Q test and I-squared (I2). To detect the potential source of heterogeneity, a subgroup analysis was conducted.
Fourteenrandomized trials were included in the quantitative analysis, and six were pooled for statistical analysis. Blueberry intervention resulted in no significant change in mood state score (WMD = 0.03; 95% CI: -0.80 to 0.87, P = 0.16). Moreover, no significant effect of blueberry intake was shown in attention task reaction time (WMD = -1.50 ms; 95% CI: -24.75 to -21.75, P = 0.9), percentages of attention task accuracy (WMD = 0.85; 95% CI: -2.57 to 0.86, P = 0.3), one-back test accuracy (WMD = 0.03; 95% CI: -0.04 to 0.09, P = 0.4). Significant effect was indicated (WMD = 0.08; 95% CI: 0.02 to 0.13, P = 0.005) in two-back test accuracy.
We found a significant effect of blueberry consumption on two-back test accuracy as a cognitive outcome. More high-quality clinical trials according to the challenges mentioned seem to indicate the use of blueberry as a supplement for cognitive and mood health efficiently.
Relevant studies, published in April 2021, were searched through PubMed/Medline, Scopus, Embase, and Google Scholar. The random effect size was used to estimate the pooled effect size. Heterogeneity between studies was evaluated by the Cochrane Q test and I-squared (I2). To detect the potential source of heterogeneity, a subgroup analysis was conducted.
Fourteenrandomized trials were included in the quantitative analysis, and six were pooled for statistical analysis. Blueberry intervention resulted in no significant change in mood state score (WMD = 0.03; 95% CI: -0.80 to 0.87, P = 0.16). Moreover, no significant effect of blueberry intake was shown in attention task reaction time (WMD = -1.50 ms; 95% CI: -24.75 to -21.75, P = 0.9), percentages of attention task accuracy (WMD = 0.85; 95% CI: -2.57 to 0.86, P = 0.3), one-back test accuracy (WMD = 0.03; 95% CI: -0.04 to 0.09, P = 0.4). Significant effect was indicated (WMD = 0.08; 95% CI: 0.02 to 0.13, P = 0.005) in two-back test accuracy.
We found a significant effect of blueberry consumption on two-back test accuracy as a cognitive outcome. More high-quality clinical trials according to the challenges mentioned seem to indicate the use of blueberry as a supplement for cognitive and mood health efficiently.
摘要：
背景：蓝莓以其高含量的几种生物活性化合物而闻名，特别是花青素,在神经保护方面，这已被证明是favonoid家族中最有益的。已经进行了一些人体干预研究，以评估蓝莓摄入量对认知表现的影响，然而,临床试验的结果尚无定论。因此,本系统综述和荟萃分析使用基于现有证据的临床试验数据,评估了补充蓝莓对认知表现和情绪参数某些方面的影响.
方法：相关研究，直到2021年4月发布，通过PubMed/Medline搜索，Scopus,Embase和谷歌学者。随机效应大小用于估计合并效应大小。通过CochraneQ检验和I平方(I2)评估研究之间的异质性。为了检测异质性的潜在来源，进行亚组分析.
结果：14项随机试验纳入定量分析，和6个进行统计分析.蓝莓干预导致情绪状态评分无显著变化(WMD=0.03;95%CI:-0.80至0.87,P=0.16)。此外，蓝莓摄入量对注意力任务反应时间没有显着影响（WMD=-1.50ms；95％CI：-24.75至-21.75，P=0.9），注意任务准确度的百分比(WMD=0.85；95%CI：-2.57至0.86，P=0.3)，一次测试准确性（WMD=0.03；95%CI：-0.04至0.09，P=0.4）。在两次回溯测试的准确性中显示了显着的效果（WMD=0.08；95％CI：0.02至0.13，P=0.005）。
结论：我们发现食用蓝莓对认知结果的两回测试准确性有显著影响。根据提到的挑战，更多高质量的临床试验似乎表明使用蓝莓作为认知和情绪健康的补充有效。
方法：相关研究，直到2021年4月发布，通过PubMed/Medline搜索，Scopus,Embase和谷歌学者。随机效应大小用于估计合并效应大小。通过CochraneQ检验和I平方(I2)评估研究之间的异质性。为了检测异质性的潜在来源，进行亚组分析.
结果：14项随机试验纳入定量分析，和6个进行统计分析.蓝莓干预导致情绪状态评分无显著变化(WMD=0.03;95%CI:-0.80至0.87,P=0.16)。此外，蓝莓摄入量对注意力任务反应时间没有显着影响（WMD=-1.50ms；95％CI：-24.75至-21.75，P=0.9），注意任务准确度的百分比(WMD=0.85；95%CI：-2.57至0.86，P=0.3)，一次测试准确性（WMD=0.03；95%CI：-0.04至0.09，P=0.4）。在两次回溯测试的准确性中显示了显着的效果（WMD=0.08；95％CI：0.02至0.13，P=0.005）。
结论：我们发现食用蓝莓对认知结果的两回测试准确性有显著影响。根据提到的挑战，更多高质量的临床试验似乎表明使用蓝莓作为认知和情绪健康的补充有效。
