Abstract：
BACKGROUND: Diagnosis of MALT lymphoma in the oral cavity is challenging. There is a great overlap in the histopathologic, immuno-histochemical and molecular features of MALT lymphoma with reactive lymphoid proliferations. The literature shows a very few case reports of primary MALT lymphoma of oral cavity.
METHODS: We discuss the histopathologic, immuno-histochemical, cytogenetic features, treatment and behavior of 3 cases of primary MALT lymphoma oral cavity along with review of literature.
RESULTS: The age ranged from 40 to 57 years (male to female ratio = 2:1). The sites involved were hard palate, bilateral gingivobuccal sulcus and right buccal mucosa. The most common histology was centrocyte-like (2 cases). Lymphoepithelial lesions were absent. On immunohistochemistry, all tumors showed diffuse strong CD20 and bcl2 expression with strong and diffuse MNDA staining in one case. IgH; MALT1 translocation was not seen in any of these cases. One patient received local radiotherapy, one received steroids; while the case 3 received RCHOP (Rituximab, cyclophosphamide, hydroxydaunorubicin hydrochloride, vincristine and prednisone) chemotherapy. Two patients had complete remission while one had recurrence.
CONCLUSIONS: MALT lymphoma of oral cavity shows a wide spectrum of morphology with presence of transformed cells, that may lead to misdiagnosis of DLBL. Treatment guidelines are not well established but a tendency to excise MALT lymphomas of oral cavity has been observed. Nevertheless, MALT lymphoma of oral cavity appears to be an indolent disease.
METHODS: We discuss the histopathologic, immuno-histochemical, cytogenetic features, treatment and behavior of 3 cases of primary MALT lymphoma oral cavity along with review of literature.
RESULTS: The age ranged from 40 to 57 years (male to female ratio = 2:1). The sites involved were hard palate, bilateral gingivobuccal sulcus and right buccal mucosa. The most common histology was centrocyte-like (2 cases). Lymphoepithelial lesions were absent. On immunohistochemistry, all tumors showed diffuse strong CD20 and bcl2 expression with strong and diffuse MNDA staining in one case. IgH; MALT1 translocation was not seen in any of these cases. One patient received local radiotherapy, one received steroids; while the case 3 received RCHOP (Rituximab, cyclophosphamide, hydroxydaunorubicin hydrochloride, vincristine and prednisone) chemotherapy. Two patients had complete remission while one had recurrence.
CONCLUSIONS: MALT lymphoma of oral cavity shows a wide spectrum of morphology with presence of transformed cells, that may lead to misdiagnosis of DLBL. Treatment guidelines are not well established but a tendency to excise MALT lymphomas of oral cavity has been observed. Nevertheless, MALT lymphoma of oral cavity appears to be an indolent disease.
摘要：
背景：口腔MALT淋巴瘤的诊断具有挑战性。在组织病理学上有很大的重叠，具有反应性淋巴增生的MALT淋巴瘤的免疫组织化学和分子特征。文献显示口腔原发性MALT淋巴瘤的病例报道很少。
方法：我们讨论了组织病理学，免疫组织化学,细胞遗传学特征，3例原发性口腔MALT淋巴瘤的治疗及表现并文献复习。
结果：年龄范围为40至57岁（男女比例=2：1）。涉及的地点是硬腭，双侧龈沟和右侧颊粘膜。最常见的组织学类型为中心细胞样（2例）。无淋巴上皮病变。关于免疫组织化学，所有肿瘤均表现为弥漫性强CD20和bcl2表达，其中1例具有强弥漫性MNDA染色。IgH;在这些病例中均未见到MALT1易位。一名患者接受了局部放疗，1人接受类固醇治疗；而3人接受RCHOP（利妥昔单抗，环磷酰胺,盐酸羟基柔红霉素,长春新碱和泼尼松）化疗。两名患者完全缓解，一名复发。
结论：口腔MALT淋巴瘤表现出广泛的形态，存在转化细胞，这可能导致DLBL的误诊。治疗指南尚未建立，但已观察到切除口腔MALT淋巴瘤的趋势。然而，口腔MALT淋巴瘤似乎是一种惰性疾病。
方法：我们讨论了组织病理学，免疫组织化学,细胞遗传学特征，3例原发性口腔MALT淋巴瘤的治疗及表现并文献复习。
结果：年龄范围为40至57岁（男女比例=2：1）。涉及的地点是硬腭，双侧龈沟和右侧颊粘膜。最常见的组织学类型为中心细胞样（2例）。无淋巴上皮病变。关于免疫组织化学，所有肿瘤均表现为弥漫性强CD20和bcl2表达，其中1例具有强弥漫性MNDA染色。IgH;在这些病例中均未见到MALT1易位。一名患者接受了局部放疗，1人接受类固醇治疗；而3人接受RCHOP（利妥昔单抗，环磷酰胺,盐酸羟基柔红霉素,长春新碱和泼尼松）化疗。两名患者完全缓解，一名复发。
结论：口腔MALT淋巴瘤表现出广泛的形态，存在转化细胞，这可能导致DLBL的误诊。治疗指南尚未建立，但已观察到切除口腔MALT淋巴瘤的趋势。然而，口腔MALT淋巴瘤似乎是一种惰性疾病。
