METHODS: We discuss the histopathologic, immuno-histochemical, cytogenetic features, treatment and behavior of 3 cases of primary MALT lymphoma oral cavity along with review of literature.
RESULTS: The age ranged from 40 to 57 years (male to female ratio = 2:1). The sites involved were hard palate, bilateral gingivobuccal sulcus and right buccal mucosa. The most common histology was centrocyte-like (2 cases). Lymphoepithelial lesions were absent. On immunohistochemistry, all tumors showed diffuse strong CD20 and bcl2 expression with strong and diffuse MNDA staining in one case. IgH; MALT1 translocation was not seen in any of these cases. One patient received local radiotherapy, one received steroids; while the case 3 received RCHOP (Rituximab, cyclophosphamide, hydroxydaunorubicin hydrochloride, vincristine and prednisone) chemotherapy. Two patients had complete remission while one had recurrence.
CONCLUSIONS: MALT lymphoma of oral cavity shows a wide spectrum of morphology with presence of transformed cells, that may lead to misdiagnosis of DLBL. Treatment guidelines are not well established but a tendency to excise MALT lymphomas of oral cavity has been observed. Nevertheless, MALT lymphoma of oral cavity appears to be an indolent disease.
方法:我们讨论了组织病理学,免疫组织化学,细胞遗传学特征,3例原发性口腔MALT淋巴瘤的治疗及表现并文献复习。
结果:年龄范围为40至57岁(男女比例=2:1)。涉及的地点是硬腭,双侧龈沟和右侧颊粘膜。最常见的组织学类型为中心细胞样(2例)。无淋巴上皮病变。关于免疫组织化学,所有肿瘤均表现为弥漫性强CD20和bcl2表达,其中1例具有强弥漫性MNDA染色。IgH;在这些病例中均未见到MALT1易位。一名患者接受了局部放疗,1人接受类固醇治疗;而3人接受RCHOP(利妥昔单抗,环磷酰胺,盐酸羟基柔红霉素,长春新碱和泼尼松)化疗。两名患者完全缓解,一名复发。
结论:口腔MALT淋巴瘤表现出广泛的形态,存在转化细胞,这可能导致DLBL的误诊。治疗指南尚未建立,但已观察到切除口腔MALT淋巴瘤的趋势。然而,口腔MALT淋巴瘤似乎是一种惰性疾病。