Abstract：
Gastrointestinal (GI) cancer is associated with a group of cancers affecting the organs in the GI tract, with a high incidence and mortality rate. This type of cancer development involves a series of molecular events that arise by the dysregulation of gene expressions and microRNAs (miRNAs).
This mini-review focuses on elucidating the mechanism of tumor suppressor miRNA-mediated oncogenic gene silencing, which may contribute to a better understanding of miRNA-mediated gene expression regulation of cell cycle, proliferation, invasion, and apoptosis in GI cancers. In this review, the biological significance of tumor suppressor miRNAs involved in gastrointestinal cancers is briefly explained.
The articles were searched with the keywords \'miRNA\', \'gastrointestinal cancers\', \'esophageal cancer\', \'gastric cancer\', \'colorectal cancer\', \'pancreatic cancer\', \'liver cancer\', and \'gall bladder cancer\' from the Google Scholar and PubMed databases. A total of 71 research and review articles have been collected and referred for this study.
This review summarises recent research enhancing the effectiveness of miRNAs as novel prognostic, diagnostic, and therapeutic markers for GI cancer treatment strategies. The expression pattern of various miRNAs has been dysregulated in GI cancers, which are associated with proliferation, cell cycle regulation, apoptosis, migration, and invasion.
The role of tumor suppressor miRNAs in the negative regulation of oncogenic gene expression was thoroughly explained in this review. Its potential role as a microRNA therapeutic candidate is also discussed. Profiling and regulating tumor suppressor miRNA expression in gastrointestinal cancers using miRNA mimics could be used as a prognostic, diagnostic, and therapeutic marker, as well as an elucidating molecular therapeutic approach to tumor suppression.
This mini-review focuses on elucidating the mechanism of tumor suppressor miRNA-mediated oncogenic gene silencing, which may contribute to a better understanding of miRNA-mediated gene expression regulation of cell cycle, proliferation, invasion, and apoptosis in GI cancers. In this review, the biological significance of tumor suppressor miRNAs involved in gastrointestinal cancers is briefly explained.
The articles were searched with the keywords \'miRNA\', \'gastrointestinal cancers\', \'esophageal cancer\', \'gastric cancer\', \'colorectal cancer\', \'pancreatic cancer\', \'liver cancer\', and \'gall bladder cancer\' from the Google Scholar and PubMed databases. A total of 71 research and review articles have been collected and referred for this study.
This review summarises recent research enhancing the effectiveness of miRNAs as novel prognostic, diagnostic, and therapeutic markers for GI cancer treatment strategies. The expression pattern of various miRNAs has been dysregulated in GI cancers, which are associated with proliferation, cell cycle regulation, apoptosis, migration, and invasion.
The role of tumor suppressor miRNAs in the negative regulation of oncogenic gene expression was thoroughly explained in this review. Its potential role as a microRNA therapeutic candidate is also discussed. Profiling and regulating tumor suppressor miRNA expression in gastrointestinal cancers using miRNA mimics could be used as a prognostic, diagnostic, and therapeutic marker, as well as an elucidating molecular therapeutic approach to tumor suppression.
摘要：
背景：胃肠道（GI）癌症与影响胃肠道器官的一组癌症有关，具有很高的发病率和死亡率。这种类型的癌症发展涉及一系列由基因表达和microRNAs（miRNA）失调引起的分子事件。
目的：本综述主要探讨miRNA介导的肿瘤抑制基因沉默的机制。这可能有助于更好地理解miRNA介导的细胞周期基因表达调控，扩散,入侵,和胃肠道癌症中的细胞凋亡。在这次审查中,简要解释了参与胃肠道肿瘤的肿瘤抑制miRNAs的生物学意义。
方法：使用关键字\'miRNA\'搜索文章，\'胃肠道癌症\'，\'食道癌\',\'胃癌\',\'结直肠癌\',\'胰腺癌\',\'肝癌\',和“胆囊癌”来自谷歌学者和PubMed数据库。本研究共收集并引用了71篇研究和综述文章。
结果：这篇综述总结了最近的研究，提高了miRNAs作为新预后的有效性，诊断,和胃肠道癌症治疗策略的治疗标志物。各种miRNA的表达模式在胃肠道肿瘤中失调,与增殖有关，细胞周期调节，凋亡，迁移,和入侵。
结论：本文对肿瘤抑制miRNAs在癌基因表达负调控中的作用进行了全面阐述。还讨论了其作为microRNA治疗候选物的潜在作用。使用miRNA模拟物分析和调节胃肠道肿瘤中的肿瘤抑制miRNA表达可用作预后,诊断,和治疗标记，以及阐明肿瘤抑制的分子治疗方法。
目的：本综述主要探讨miRNA介导的肿瘤抑制基因沉默的机制。这可能有助于更好地理解miRNA介导的细胞周期基因表达调控，扩散,入侵,和胃肠道癌症中的细胞凋亡。在这次审查中,简要解释了参与胃肠道肿瘤的肿瘤抑制miRNAs的生物学意义。
方法：使用关键字\'miRNA\'搜索文章，\'胃肠道癌症\'，\'食道癌\',\'胃癌\',\'结直肠癌\',\'胰腺癌\',\'肝癌\',和“胆囊癌”来自谷歌学者和PubMed数据库。本研究共收集并引用了71篇研究和综述文章。
结果：这篇综述总结了最近的研究，提高了miRNAs作为新预后的有效性，诊断,和胃肠道癌症治疗策略的治疗标志物。各种miRNA的表达模式在胃肠道肿瘤中失调,与增殖有关，细胞周期调节，凋亡，迁移,和入侵。
结论：本文对肿瘤抑制miRNAs在癌基因表达负调控中的作用进行了全面阐述。还讨论了其作为microRNA治疗候选物的潜在作用。使用miRNA模拟物分析和调节胃肠道肿瘤中的肿瘤抑制miRNA表达可用作预后,诊断,和治疗标记，以及阐明肿瘤抑制的分子治疗方法。
