PDF(Pubmed)
Abstract：
In addition to the therapeutic agent, drugs contain excipients such as stabilizers, preservatives, solubilizers, or dyes, some of which are identical to additives in foods. Anaphylaxis to these excipients is probably an underestimated problem. After the first descriptions of anaphylactic reactions to drug excipients appeared more than 30 years ago, the number of corresponding reports has increased significantly over the years. However, a diagnostic gap exists in the clarification of drug allergic reactions when the index product is not known and/or is not available for testing. In the present work, individual excipients are presented as examples for which publications on anaphylaxis are available. Furthermore, the options of allergological testing both in vivo and in vitro are discussed. The pathogenesis of such reactions is still unresolved in many cases, and current concepts are briefly presented in the conclusion. With increasing knowledge about anaphylaxis to drug excipients, it is assumed that these can then be recognized more often and diagnostically clarified.
摘要：
除了治疗剂，药物含有赋形剂，如稳定剂，防腐剂,增溶剂,或者染料，其中一些与食品中的添加剂相同。对这些赋形剂的过敏反应可能是一个被低估的问题。在30多年前出现了对药物赋形剂的过敏反应的首次描述之后，多年来，相应的报告数量大幅增加。然而,当索引产品未知和/或不可用于测试时，在澄清药物过敏反应方面存在诊断差距。在目前的工作中,单独的赋形剂作为例子，关于过敏反应的出版物是可用的。此外，讨论了体内和体外过敏测试的选择。这种反应的发病机制在许多情况下仍未解决,结论中简要介绍了当前的概念。随着对药物赋形剂过敏反应的了解不断增加，假设这些可以更频繁地识别并在诊断上得到澄清。
