PDF(Pubmed)
Abstract：
Background There has been an increase in non-tuberculous mycobacteria (NTM) infection reports in humans. Surgeons are concerned about the link between them and surgical site infections. As a result, it has been challenging to determine just how common this illness is. A two-year study by the authors examines the occurrence of NTM infections after different surgical procedures. Design and methods Researchers at a tertiary care hospital in central India performed this prospective study over two years. NTM was found in six of the 25 instances of post-surgical wound infections. Ziehl-Neelsen staining, Auramine O-Rhodamine fluorescence staining, Multiplex Real-Time PCR, and Genotyping were used to identify the species. Results M. fortuitum, M. chelonae and M.kansasii were isolated from discharge in 2 cases each respectively. NTM isolates evaluated for antibiotic susceptibility pattern were all sensitive to Clarithromycin (100%). One case with prolonged healing had to be intervened with amikacin along with clarithromycin. Conclusion NTM is an infection of uncommon nature which can occur following surgical procedures. Identification of these organisms through sensitive techniques and appropriate therapeutic regimen formulation must be done to tackle this growing menace in health care setups.
摘要：
背景技术人类中的非结核分枝杆菌(NTM)感染报告已经增加。外科医生担心它们与手术部位感染之间的联系。因此,确定这种疾病有多普遍一直很有挑战性。作者进行的一项为期两年的研究检查了不同外科手术后NTM感染的发生。设计和方法印度中部三级医院的研究人员进行了为期两年的前瞻性研究。在25例术后伤口感染中的6例中发现了NTM。Ziehl-Neelsen染色,金胺O-罗丹明荧光染色,多重实时PCR,和基因分型用于鉴定物种。结果M.fortuitum，分别从排出物中分离出鱼皮分枝杆菌和坎萨西分枝杆菌各2例。评估抗生素敏感性模式的NTM分离物均对克拉霉素敏感（100％）。1例长期愈合的病例必须用阿米卡星和克拉霉素进行干预。结论NTM是一种罕见的感染，可在外科手术后发生。必须通过敏感技术和适当的治疗方案制定来鉴定这些生物体，以应对医疗保健设置中日益增长的威胁。
