PDF(Pubmed)
Abstract：
UNASSIGNED: Molluscum contagiosum (MC) is a common viral cutaneous infection. Despite multiple treatment options, there is no definitive treatment. In some cases, the lesions are severe, recurrent, and cosmetically odd. Modified autoinoculation (MAI) is a novel technique that induces cell-mediated immunity resulting in clearance of local as well as distant lesions. Potassium hydroxide (KOH) acts by dissolving the keratin and penetrating deeply destroys the hyperproliferative tissue. We would here like to compare MAI with topical KOH in the treatment of MC.
UNASSIGNED: The aim of this study was to assess the effectiveness of MAI in treatment of MC and to compare its response with topical KOH application.
UNASSIGNED: This was an open-labeled longitudinal therapeutic outcome study carried out at a tertiary care center over a period of 1 year.
UNASSIGNED: Hundred consenting MC patients attending the department of dermatology were randomized into Group A and Group B. Group A patients were subjected to MAI and Group B to topical application of 10% KOH.
UNASSIGNED: The continuous variables are presented as mean ± standard deviation (SD). The difference between the mean score was analyzed using Student\'s t test for independent variable and paired t test for paired results.
UNASSIGNED: At the end of 16 weeks, 91.48% showed complete clearance by MAI compared to 81.64% with topical 10% KOH solution. There was a significant reduction of mean score of lesions in patients treated by MAI compared to patients treated with KOH.
UNASSIGNED: MAI therapy provides a promising, easy, cost-effective, daycare option for MC infections.
UNASSIGNED: The aim of this study was to assess the effectiveness of MAI in treatment of MC and to compare its response with topical KOH application.
UNASSIGNED: This was an open-labeled longitudinal therapeutic outcome study carried out at a tertiary care center over a period of 1 year.
UNASSIGNED: Hundred consenting MC patients attending the department of dermatology were randomized into Group A and Group B. Group A patients were subjected to MAI and Group B to topical application of 10% KOH.
UNASSIGNED: The continuous variables are presented as mean ± standard deviation (SD). The difference between the mean score was analyzed using Student\'s t test for independent variable and paired t test for paired results.
UNASSIGNED: At the end of 16 weeks, 91.48% showed complete clearance by MAI compared to 81.64% with topical 10% KOH solution. There was a significant reduction of mean score of lesions in patients treated by MAI compared to patients treated with KOH.
UNASSIGNED: MAI therapy provides a promising, easy, cost-effective, daycare option for MC infections.
摘要：
■传染性软疣（MC）是一种常见的病毒性皮肤感染。尽管有多种治疗选择,没有明确的治疗方法。在某些情况下,病变很严重,经常性,外观上很奇怪。改良的自体接种（MAI）是一种新型技术，可诱导细胞介导的免疫，从而清除局部和远处的病变。氢氧化钾(KOH)通过溶解角蛋白和穿透深度破坏过度增殖组织而起作用。我们在这里想比较MAI与局部KOH在MC治疗中的作用。
■本研究的目的是评估MAI治疗MC的有效性，并比较其与局部KOH应用的反应。
■这是一项在三级护理中心进行的为期1年的开放标记的纵向治疗结果研究。
■将参加皮肤科的一百名同意的MC患者随机分为A组和B组。A组患者接受MAI治疗，B组患者局部应用10％KOH。
■连续变量表示为平均值±标准偏差（SD）。使用Student'st检验对自变量进行分析，并使用配对t检验对配对结果进行分析。
■在16周结束时，通过MAI,91.48%显示完全清除率,与局部10%KOH溶液的81.64%相比。与用KOH治疗的患者相比，用MAI治疗的患者的平均病变评分显着降低。
■MAI疗法提供了一种有希望的，easy,成本效益高,MC感染的日托选择。
■本研究的目的是评估MAI治疗MC的有效性，并比较其与局部KOH应用的反应。
■这是一项在三级护理中心进行的为期1年的开放标记的纵向治疗结果研究。
■将参加皮肤科的一百名同意的MC患者随机分为A组和B组。A组患者接受MAI治疗，B组患者局部应用10％KOH。
■连续变量表示为平均值±标准偏差（SD）。使用Student'st检验对自变量进行分析，并使用配对t检验对配对结果进行分析。
■在16周结束时，通过MAI,91.48%显示完全清除率,与局部10%KOH溶液的81.64%相比。与用KOH治疗的患者相比，用MAI治疗的患者的平均病变评分显着降低。
■MAI疗法提供了一种有希望的，easy,成本效益高,MC感染的日托选择。
