PDF(Pubmed)
Abstract：
Maternal Group B Streptococcus (GBS) recto-vaginal colonization is the most common route for early onset neonatal GBS diseases. A good understanding of the rate of maternal GBS colonization, vertical transmission rate, and antibiotic susceptibility profiles is needed to formulate a broad protection mechanism, like vaccine preparation. For that reason, this meta-analysis aimed at determining the pooled prevalence of GBS recto-vaginal colonization, vertical transmission rate, and antibiotic susceptibility profiles in Ethiopia.
Both published and unpublished studies were searched from MEDLINE/PubMed, CINAHL (EBSCO), Embase, Cochrane Library, SCOPUS, Web of Sciences databases, and Google Scholar. Independent selection was then carried out by the authors based on the eligibility criteria and data extraction using Microsoft excel. The authors then used STATA version 14.1 software for further cleaning and analysis. The review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses) PRISMA guidelines. Using the random-effect model, the prevalence with a 95% confidence interval (CI) and forest plot were used to present the findings. Besides, the studies\' heterogeneity was assessed using Cochrane chi-square (I2) statistics, while Egger intercept was used to assess publication bias.
This review included nineteen studies. The pooled prevalence of recto-vaginal colonization was 15% (95% CI: 11, 19), while the prevalence of vertical transmission was 51% (95% CI: 45, 58) and highest-level susceptibility to vancomycin was 99% (95% CI: 98, 100). However, the GBS susceptibility to tetracycline was 23% (95% CI: 9, 36).
Nearly one out of seven pregnant women in Ethiopia had recto-vaginal colonization of GBS. As a result, half of the pregnancies end with vertical transmission of GBS. Hence, the review emphasizes that policy and programs should consider planning and implementing prophylactic programs.
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021287540.
Both published and unpublished studies were searched from MEDLINE/PubMed, CINAHL (EBSCO), Embase, Cochrane Library, SCOPUS, Web of Sciences databases, and Google Scholar. Independent selection was then carried out by the authors based on the eligibility criteria and data extraction using Microsoft excel. The authors then used STATA version 14.1 software for further cleaning and analysis. The review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses) PRISMA guidelines. Using the random-effect model, the prevalence with a 95% confidence interval (CI) and forest plot were used to present the findings. Besides, the studies\' heterogeneity was assessed using Cochrane chi-square (I2) statistics, while Egger intercept was used to assess publication bias.
This review included nineteen studies. The pooled prevalence of recto-vaginal colonization was 15% (95% CI: 11, 19), while the prevalence of vertical transmission was 51% (95% CI: 45, 58) and highest-level susceptibility to vancomycin was 99% (95% CI: 98, 100). However, the GBS susceptibility to tetracycline was 23% (95% CI: 9, 36).
Nearly one out of seven pregnant women in Ethiopia had recto-vaginal colonization of GBS. As a result, half of the pregnancies end with vertical transmission of GBS. Hence, the review emphasizes that policy and programs should consider planning and implementing prophylactic programs.
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021287540.
摘要：
母体B族链球菌（GBS）直肠阴道定植是早发性新生儿GBS疾病的最常见途径。对母体GBS定植率有很好的了解，垂直传输速率,需要抗生素敏感性来制定广泛的保护机制，比如疫苗准备。出于这个原因,这项荟萃分析旨在确定GBS直肠阴道定植的合并患病率，垂直传输速率,和埃塞俄比亚的抗生素敏感性概况。
已发表和未发表的研究均从MEDLINE/PubMed检索，CINAHL(EBSCO)，Embase,科克伦图书馆,Scopus,WebofSciences数据库,谷歌学者。然后由作者根据资格标准和使用Microsoftexcel的数据提取进行独立选择。然后，作者使用STATA14.1版软件进行进一步的清洁和分析。审查基于系统审查和荟萃分析的首选报告项目）PRISMA指南。使用随机效应模型，使用95%置信区间(CI)的患病率和森林地块来呈现研究结果.此外,使用Cochrane卡方(I2)统计量评估研究的异质性，而Egger截距用于评估发表偏倚。
本综述包括19项研究。直肠阴道定植的合并患病率为15％（95％CI：11，19），而垂直传播的患病率为51%(95%CI:45,58),万古霉素的最高敏感性为99%(95%CI:98,100).然而,GBS对四环素的敏感性为23%(95%CI:9,36)。
埃塞俄比亚近七分之一的孕妇有GBS的阴道直肠定植。因此,一半的妊娠以GBS的垂直传播结束。因此，审查强调，政策和计划应考虑计划和实施预防计划。
https://www。crd.约克。AC.uk/prospro/display_record.php?ID=CRD42021287540。
已发表和未发表的研究均从MEDLINE/PubMed检索，CINAHL(EBSCO)，Embase,科克伦图书馆,Scopus,WebofSciences数据库,谷歌学者。然后由作者根据资格标准和使用Microsoftexcel的数据提取进行独立选择。然后，作者使用STATA14.1版软件进行进一步的清洁和分析。审查基于系统审查和荟萃分析的首选报告项目）PRISMA指南。使用随机效应模型，使用95%置信区间(CI)的患病率和森林地块来呈现研究结果.此外,使用Cochrane卡方(I2)统计量评估研究的异质性，而Egger截距用于评估发表偏倚。
本综述包括19项研究。直肠阴道定植的合并患病率为15％（95％CI：11，19），而垂直传播的患病率为51%(95%CI:45,58),万古霉素的最高敏感性为99%(95%CI:98,100).然而,GBS对四环素的敏感性为23%(95%CI:9,36)。
埃塞俄比亚近七分之一的孕妇有GBS的阴道直肠定植。因此,一半的妊娠以GBS的垂直传播结束。因此，审查强调，政策和计划应考虑计划和实施预防计划。
https://www。crd.约克。AC.uk/prospro/display_record.php?ID=CRD42021287540。
