马兜铃酸暴露不是成年期肝脏肿瘤发生的主要原因。
关键词: AAI, Aristolochic acid I AAs, aristolochic acids AA–DNA adduct AFP, alpha fetoprotein AL, aristolactam ALT, alanine aminotransferase AST, aspartate aminotransferase Aristolochic acids (AAs) CHERRY, Chinese Electronic Health Records Research COSMIC, Catalogue of Somatic Mutations in Cancer CRE, creatinine DEN, N-nitrosodiethylamine EHBH, Eastern Hepatobiliary Surgery Hospital FFPE, formalin-fixed paraffin-embedded HBV, hepatitis B virus HCC, hepatocellular carcinoma Hepatitis B virus (HBV) Hepatocellular carcinoma (HCC) Liver tumorigenesis MVI, microvessel invasion Mutational signature Risk factors SNV, somatic single nucleotide variant TCGA, The Cancer Genome Atlas Tumor prevention WGS, whole genome sequencing WT, wild type dA-ALI, 7-deoxyadenosin-N6-yl aristolactam I
来 源:
DOI:10.1016/j.apsb.2021.11.011
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