Abstract：
Introduction: There are few reports on the effect of radiation alone on blood cells (without chemotherapy). We sought to develop a single source as a reference. Materials and Methods: For over 300 prostate cancer patients treated with radiation alone, we collected the baseline, end-of-treatment and three-month post-therapy complete blood counts (CBC). Results: The hemoglobin dropped by a mean of 1.00 g/dL (−7.1%), with an RBC count of 0.40 × 1012 (−8.6%) at the end of treatment and remained significantly (but <5%) below baseline at follow-up. Significant declines were seen in the levels of the granulocytes (−12.2%; −0.67 × 109), monocytes (−2.2%; −0.05 × 109) and platelets (−12.7%; −30.31 × 109) at the end of treatment, but all returned to baseline on follow-up. The neutrophils and basophils (the primary components of the granulocytes) suffered a significant decline but returned to baseline by the follow-up. The other granulocyte components, the eosinophils, did not decline significantly. The most dramatic decline was in the levels of lymphocytes −62.5% (−1.29 × 109), which were still significantly below baseline (−38%) after two years. Conclusion: The effect of radiation is mostly transitory, with some persistence in hemoglobin/erythrocyte levels (<5%). Lymphocytes are slower to recover, remaining significantly below baseline after two years. It is noteworthy that of the patients whose lymphocytes were in the normal range at the start of therapy, only 14% were below normal at follow-up. Radiation alone has negligible-to-modest long-term effects on blood counts.
摘要：
简介：关于单独辐射对血细胞的影响（不进行化疗）的报道很少。我们试图开发一个单一的来源作为参考。材料和方法：对于300多名单独接受放射治疗的前列腺癌患者，我们收集了基线，治疗结束和治疗后三个月的全血细胞计数（CBC）。结果：血红蛋白平均下降1.00g/dL(−7.1%)，治疗结束时RBC计数为0.40×1012(−8.6%)，随访时仍显著低于基线(但<5%)。粒细胞水平显著下降(−12.2%；−0.67×109)，治疗结束时单核细胞（−2.2%；−0.05×109）和血小板（−12.7%；−30.31×109），但所有的随访都回到了基线.中性粒细胞和嗜碱性粒细胞（粒细胞的主要成分）显着下降，但通过随访恢复到基线。其他粒细胞成分，嗜酸性粒细胞，没有明显下降。最显著的下降是淋巴细胞水平-62.5%（-1.29×109），两年后仍显著低于基线(−38%)。结论：辐射的影响大多是短暂的，血红蛋白/红细胞水平持续存在（<5％）。淋巴细胞恢复较慢，两年后仍显著低于基线。值得注意的是，在治疗开始时淋巴细胞处于正常范围的患者中，随访时只有14%低于正常水平.仅辐射对血细胞计数的长期影响可以忽略不计。
