Abstract：
Der p 23 is a major allergen of Dermatophagoides pteronyssinus, which could contribute to allergic asthma. The study compared the cytokine profile (Il-1beta, Il-4, Il-5, Il-6, Il-13, Il-17, TNF-alpha) in patients with allergic asthma, with confirmed allergy to D. pteronyssinus and with the presence or absence of allergy to Der p 23.
Among 173 included patients, the following combinations were analyzed: profile A - Der p 1 (+), Der p 2 (+), and Der p 23 (-) observed in 38 (22%) patients; profile B - Der p 1 (+), Der p 2 (+), and Der p 23 (+) in 87 (50.3%) patients; and profile C - Der p 1 (-), Der p 2 (-), and Der p 23 (+) in 15 (8.7%) patients.
The mean concentration of Il-1beta was significantly lower in profile A than in profiles B and C: 10.51 ± 5.22 (pg/ml) vs. 21.92 ± 11.34 vs. 23.1 ± 8.56 (A vs. B for p = 0.03 and A vs. C for p = 0.019). Similar trends were observed for Il-5: 38.5 ± 10.45 (pg/ml) vs. 94.8 ± 54.11 vs. 103.61 ± 34.9 (A vs. B for p = 0.008 and A vs. C for p = 0.001).
The higher Il-1 and Il-5 activities observed in profiles B and C with Der p 23 (+) could be responsible for the more effective acceleration of allergic inflammation than in profile A with Der p 23.
Among 173 included patients, the following combinations were analyzed: profile A - Der p 1 (+), Der p 2 (+), and Der p 23 (-) observed in 38 (22%) patients; profile B - Der p 1 (+), Der p 2 (+), and Der p 23 (+) in 87 (50.3%) patients; and profile C - Der p 1 (-), Der p 2 (-), and Der p 23 (+) in 15 (8.7%) patients.
The mean concentration of Il-1beta was significantly lower in profile A than in profiles B and C: 10.51 ± 5.22 (pg/ml) vs. 21.92 ± 11.34 vs. 23.1 ± 8.56 (A vs. B for p = 0.03 and A vs. C for p = 0.019). Similar trends were observed for Il-5: 38.5 ± 10.45 (pg/ml) vs. 94.8 ± 54.11 vs. 103.61 ± 34.9 (A vs. B for p = 0.008 and A vs. C for p = 0.001).
The higher Il-1 and Il-5 activities observed in profiles B and C with Der p 23 (+) could be responsible for the more effective acceleration of allergic inflammation than in profile A with Der p 23.
摘要：
Derp23是翼状细胞的主要过敏原，这可能会导致过敏性哮喘。该研究比较了细胞因子谱(IL-1β，Il-4，Il-5，Il-6，Il-13，Il-17，TNF-α）在过敏性哮喘患者中，已证实对D.pteronysinus过敏，是否对Derp23过敏。
在纳入的173名患者中，分析了以下组合：剖面A-Derp1(+)，Derp2(+),在38例(22%)患者中观察到Derp23(-)；概况B-Derp1(+)，Derp2(+),87例(50.3%)患者的Derp23(+)；和概况C-Derp1(-)，第2页(-)，15例(8.7%)患者的Derp23(+)。
曲线A中IL-1β的平均浓度明显低于曲线B和C：10.51±5.22（pg/ml）与21.92±11.34vs.23.1±8.56(A与B为p=0.03，A与C为p=0.019)。对于Il-5观察到类似的趋势：38.5±10.45（pg/ml）与94.8±54.11vs.103.61±34.9(A与B为p=0.008，A与C为p=0.001)。
在具有Derp23(+)的曲线B和C中观察到的更高的Il-1和Il-5活性可能是比具有Derp23的曲线A更有效地加速过敏性炎症的原因。
在纳入的173名患者中，分析了以下组合：剖面A-Derp1(+)，Derp2(+),在38例(22%)患者中观察到Derp23(-)；概况B-Derp1(+)，Derp2(+),87例(50.3%)患者的Derp23(+)；和概况C-Derp1(-)，第2页(-)，15例(8.7%)患者的Derp23(+)。
曲线A中IL-1β的平均浓度明显低于曲线B和C：10.51±5.22（pg/ml）与21.92±11.34vs.23.1±8.56(A与B为p=0.03，A与C为p=0.019)。对于Il-5观察到类似的趋势：38.5±10.45（pg/ml）与94.8±54.11vs.103.61±34.9(A与B为p=0.008，A与C为p=0.001)。
在具有Derp23(+)的曲线B和C中观察到的更高的Il-1和Il-5活性可能是比具有Derp23的曲线A更有效地加速过敏性炎症的原因。
