Abstract：
UNASSIGNED: The number of circulating tumor cells (CTCs) and the presence of circulating tumor microemboli (CTM) were determined in the peripheral blood of patients with liver cancer (LC). The relationship between CTCs, CTM, clinicopathologic features, and prognosis of LC was analyzed. The objective of this study was to determine the diagnostic and prognostic value of CTCs/CTM in LC.
UNASSIGNED: Patients with LC were enrolled between May 2013 and August 2017, and 67 patients were included in the study. Overall survival curves were built using the Kaplan-Meier method and the log-rank test to identify risk factors. The results were analyzed using a Cox proportional hazards model and expressed as hazard ratio and 95% confidence interval (95% CI).
UNASSIGNED: CTCs and either CTCs or CTM were detected in 27 patients (40.3%) and 29 patients (43.3%). CTM were found in four patients. One-year, 3-year, and 5-year survival rates were 42%, 20%, and 15%, respectively. Univariate Cox regression analysis showed that alpha-fetoprotein (AFP), number of CTCs, presence of CTM, and positive CTC/CTM were associated with survival time. Multivariate Cox regression analysis showed that alpha fetoprotein (AFP), number of CTCs, and presence of CTM were independent risk factors for survival in patients with LC.
UNASSIGNED: There was no significant correlation between the number of CTCs, the presence of CTM, and clinicopathologic factors. AFP, number of CTCs, and presence of CTM were independent risk factors for survival in patients with LC.
UNASSIGNED: Patients with LC were enrolled between May 2013 and August 2017, and 67 patients were included in the study. Overall survival curves were built using the Kaplan-Meier method and the log-rank test to identify risk factors. The results were analyzed using a Cox proportional hazards model and expressed as hazard ratio and 95% confidence interval (95% CI).
UNASSIGNED: CTCs and either CTCs or CTM were detected in 27 patients (40.3%) and 29 patients (43.3%). CTM were found in four patients. One-year, 3-year, and 5-year survival rates were 42%, 20%, and 15%, respectively. Univariate Cox regression analysis showed that alpha-fetoprotein (AFP), number of CTCs, presence of CTM, and positive CTC/CTM were associated with survival time. Multivariate Cox regression analysis showed that alpha fetoprotein (AFP), number of CTCs, and presence of CTM were independent risk factors for survival in patients with LC.
UNASSIGNED: There was no significant correlation between the number of CTCs, the presence of CTM, and clinicopathologic factors. AFP, number of CTCs, and presence of CTM were independent risk factors for survival in patients with LC.
摘要：
■确定了肝癌（LC）患者外周血中循环肿瘤细胞（CTC）的数量和循环肿瘤微栓子（CTM）的存在。CTC之间的关系,CTM,临床病理特征，分析LC的预后。这项研究的目的是确定CTCs/CTM在LC中的诊断和预后价值。
■在2013年5月至2017年8月之间招募了LC患者，其中67名患者被纳入研究。使用Kaplan-Meier方法和对数秩检验建立总体存活曲线以识别危险因素。使用Cox比例风险模型分析结果，并表示为风险比和95％置信区间（95％CI）。
■在27例患者（40.3%）和29例患者（43.3%）中检测到CTC和CTC或CTM。在四名患者中发现了CTM。一年,3年,5年生存率为42%,20%,15%,分别。单因素Cox回归分析显示甲胎蛋白(AFP)、CTC的数量,CTM的存在，CTC/CTM阳性与生存时间相关。多因素Cox回归分析显示甲胎蛋白(AFP)、CTC的数量,CTM的存在是LC患者生存的独立危险因素。
■CTC的数量之间没有显着相关性，CTM的存在,和临床病理因素。法新社,CTC的数量,CTM的存在是LC患者生存的独立危险因素。
■在2013年5月至2017年8月之间招募了LC患者，其中67名患者被纳入研究。使用Kaplan-Meier方法和对数秩检验建立总体存活曲线以识别危险因素。使用Cox比例风险模型分析结果，并表示为风险比和95％置信区间（95％CI）。
■在27例患者（40.3%）和29例患者（43.3%）中检测到CTC和CTC或CTM。在四名患者中发现了CTM。一年,3年,5年生存率为42%,20%,15%,分别。单因素Cox回归分析显示甲胎蛋白(AFP)、CTC的数量,CTM的存在，CTC/CTM阳性与生存时间相关。多因素Cox回归分析显示甲胎蛋白(AFP)、CTC的数量,CTM的存在是LC患者生存的独立危险因素。
■CTC的数量之间没有显着相关性，CTM的存在,和临床病理因素。法新社,CTC的数量,CTM的存在是LC患者生存的独立危险因素。
