Abstract：
The intravascular behavior of tumor-derived extracellular vesicles (EVs) and circulating tumor cells (CTCs) lies at the heart of the metastatic cascade. Their capacity to disseminate and stop at specific vascular regions precedes and determines the formation of metastatic foci. We discuss in detail the central role of cellular adhesion molecules (CAMs) that are present on EV/CTC surface, as well as their endothelial ligands, in dictating their arrest site and their capacity to exit the vasculature. We focus on the differences and similarities between CAMs on CTCs and EVs, and speculate about their role in the organotropism of different cancer types. Better understanding of the binding mechanisms might pinpoint potential targets for novel therapies.
摘要：
肿瘤衍生的细胞外囊泡（EV）和循环肿瘤细胞（CTC）的血管内行为位于转移性级联的核心。它们在特定血管区域传播和停止的能力先于并决定了转移灶的形成。我们详细讨论了存在于EV/CTC表面的细胞粘附分子（CAM）的核心作用，以及它们的内皮配体，决定他们的逮捕地点和退出脉管系统的能力。我们专注于CTC和EV上的CAM之间的差异和相似之处，并推测它们在不同癌症类型的器官化中的作用。更好地了解结合机制可能会确定新疗法的潜在靶标。
