Abstract：
Preliminary methodologically limited studies suggested that taste and smell known as chemosensory impairments and neuropsychiatric symptoms are associated in post-COVID-19. The objective of this study is to evaluate whether chemosensory dysfunction and neuropsychiatric impairments in a well-characterized post-COVID-19 sample. This is a cohort study assessing adult patients hospitalized due to moderate or severe forms of COVID-19 between March and August 2020. Baseline information includes several clinical and hospitalization data. Further evaluations were made using several different reliable instruments designed to assess taste and smell functions, parosmia, and neuropsychiatric disorders (using standardized psychiatric and cognitive measures). Out of 1800 eligible individuals, 701 volunteers were assessed on this study. After multivariate analysis, patients reporting parosmia had a worse perception of memory performance (p < 0.001). Moderate/severe hypogeusia was significantly associated with a worse performance on the word list memory task (p = 0.012); Concomitant moderate/severe olfactory and gustatory loss during the acute phase of COVID-19 was also significantly associated with episodic memory impairment (p = 0.006). We found a positive association between reported chemosensory (taste and olfaction) abnormalities and cognition dysfunction in post-COVID-19 patients. These findings may help us identify potential mechanisms linking these two neurobiological functions, and also support the speculation on a possible route through which SARS-CoV-2 may reach the central nervous system.
摘要：
初步的方法学有限的研究表明，被称为化学感觉障碍和神经精神症状的味觉和嗅觉在COVID-19后与之相关。这项研究的目的是评估在特征明确的COVID-19后样本中是否存在化学感觉功能障碍和神经精神障碍。这是一项队列研究，评估2020年3月至8月间因中度或重度COVID-19而住院的成年患者。基线信息包括几个临床和住院数据。使用几种不同的可靠仪器进行了进一步的评估，旨在评估味道和气味功能，parosmia,和神经精神疾病（使用标准化的精神病学和认知措施）。在1800名符合条件的个人中，本研究对701名志愿者进行了评估。经过多变量分析，报告有假发的患者对记忆能力的感知较差(p<0.001).中度/重度嗅觉减退与单词列表记忆任务表现较差显著相关(p=0.012)；COVID-19急性期伴随的中度/重度嗅觉和味觉丧失也与情景记忆障碍显著相关(p=0.006)。我们发现，在COVID-19后患者中，已报告的化学感觉（味觉和嗅觉）异常与认知功能障碍之间存在正相关。这些发现可能有助于我们确定将这两种神经生物学功能联系起来的潜在机制，并支持对SARS-CoV-2可能到达中枢神经系统的可能途径的猜测。
