Abstract：
Human T cell leukemia virus type 1 (HTLV-1) was identified as the first pathogenic human retrovirus and is estimated to infect 5 to 10 million individuals worldwide. Unlike other retroviruses, there is no effective therapy to prevent the onset of the most alarming diseases caused by HTLV-1, and the more severe cases manifest as the malignant phenotype of adult T cell leukemia (ATL). MicroRNA (miRNA) dysfunction is a common feature of leukemogenesis, and it is no different in ATL cases. Therefore, we sought to analyze studies that reported deregulated miRNA expression in HTLV-1 infected cells and patients\' samples to understand how this deregulation could induce malignancy. Through in silico analysis, we identified 12 miRNAs that stood out in the prediction of targets, and we performed functional annotation of the genes linked to these 12 miRNAs that appeared to have a major biological interaction. A total of 90 genes were enriched in 14 KEGG pathways with significant values, including TP53, WNT, MAPK, TGF-β, and Ras signaling pathways. These miRNAs and gene interactions are discussed in further detail for elucidation of how they may act as probable drivers for ATL onset, and while our data provide solid starting points for comprehension of miRNAs\' roles in HTLV-1 infection, continuous effort in oncologic research is still needed to improve our understanding of HTLV-1 induced leukemia.
摘要：
人T细胞白血病病毒1型（HTLV-1）被确定为第一种致病性人类逆转录病毒，估计在全球范围内感染5至10百万个人。不像其他逆转录病毒,目前尚无有效的治疗方法来预防由HTLV-1引起的最令人担忧的疾病的发作，而更严重的病例表现为成人T细胞白血病（ATL）的恶性表型。microRNA（miRNA）功能障碍是白血病发生的共同特征，在ATL案例中也没有什么不同。因此,我们试图分析报道HTLV-1感染细胞和患者样本中miRNA表达失调的研究,以了解这种失调如何诱导恶性肿瘤.通过硅分析，我们鉴定了12种miRNA，它们在靶标预测中脱颖而出，我们对与这12个似乎具有主要生物学相互作用的miRNAs相关的基因进行了功能注释。共有90个基因在14个KEGG通路中富集，具有显著的价值，包括TP53，WNT，MAPK,TGF-β,和Ras信号通路。进一步详细讨论了这些miRNA和基因相互作用，以阐明它们如何作为ATL发病的可能驱动因素。虽然我们的数据为理解miRNAs在HTLV-1感染中的作用提供了坚实的起点，我们仍需要在肿瘤研究方面不断努力,以提高我们对HTLV-1诱导的白血病的认识.
