Abstract：
In this study, a system was designed that can encapsulate and deliver gallic acid (GA), which was composed of polysaccharide polymers based on sodium alginate (SA), carboxymethyl chitosan (CCT), and cellulose nanofibers (CN) and was assisted by porous starch. The compositions were characterized by rheology and zeta potentials, and the results showed that the materials used in this study could effectively guarantee the stability of the system. The morphology and chemical structure of the beads were characterized by SEM and FT-IR, the results indicated that the addition of CCT could effectively reduce the cracks and pores on the surface of the beads, which was beneficial to the encapsulation and delivery of GA. Moreover, the results of the swelling rate, release tests, and antioxidant tests also proved the effectiveness of the system. The pH response effect of SA/CN/CCT (SCC) beads and the protection of GA were superior, and the release rate of GA in simulated gastric fluid (SGF) was only 6.95%, while SA and SA/CN (SCN) beads reached 57.94% and 78.49%, respectively. In conclusion, the interpenetrating network polymers constructed by SA, CCT, and CN, which, combined with porous starch as a coating layer, can achieve the embedding and the delivery of GA.
摘要：
在这项研究中,设计了一个可以封装和递送没食子酸(GA)的系统，由基于海藻酸钠（SA）的多糖聚合物组成，羧甲基壳聚糖(CCT),和纤维素纳米纤维（CN），并由多孔淀粉辅助。该组合物的特征在于流变学和ζ电位，结果表明,本研究使用的材料能够有效地保证系统的稳定性。利用SEM和FT-IR对微球的形貌和化学结构进行了表征,结果表明,CCT的加入能有效减少微珠表面的裂纹和孔隙,有利于GA的包封和递送。此外，溶胀率的结果，释放测试,和抗氧化剂测试也证明了该系统的有效性。SA/CN/CCT(SCC)珠的pH反响后果和GA的掩护感化优越，GA在模拟胃液(SGF)中的释放率仅为6.95%,而SA和SA/CN(SCN)珠分别达到57.94%和78.49%,分别。总之,由SA构建的互穿网络聚合物，CCT,CN,which,结合多孔淀粉作为涂层，可以实现GA的嵌入和递送。
