Abstract：
T-cell receptors (TR), the antigen receptors of T cells, specifically recognize peptides presented by the major histocompatibility (MH) proteins, as peptide/MH (pMH), on the cell surface. The structure characterization of the trimolecular TR/pMH complexes is crucial to the fields of immunology, vaccination, and immunotherapy. IMGT/3Dstructure-DB is the three-dimensional (3-D) structure database of IMGT®, the international ImMunoGenetics information system®. By its creation, IMGT® marks the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. The IMGT® immunoglobulin (IG) and TR gene and allele nomenclature (CLASSIFICATION axiom) and the IMGT unique numbering and IMGT/Collier-de-Perles (NUMEROTATION axiom) are the two founding breakthroughs of immunoinformatics. IMGT-ONTOLOGY concepts and IMGT Scientific chart rules generated from these axioms allowed IMGT® bridging genes, structures, and functions. IMGT/3Dstructure-DB contains 3-D structures of IG or antibodies, TR and MH proteins of the adaptive immune responses of jawed vertebrates (gnathostomata), IG or TR complexes with antigens (IG/Ag, TR/pMH), related proteins of the immune system of any species belonging to the IG and MH superfamilies, and fusion proteins for immune applications. The focus of this chapter is on the TR V domains and MH G domains and the contact analysis comparison in TR/pMH interactions. Standardized molecular characterization includes \"IMGT pMH contact sites\" for peptide and MH groove interactions and \"IMGT paratopes and epitopes\" for TR/pMH complexes. Data are available in the IMGT/3Dstructure database, at the IMGT Home page http://www.imgt.org .
摘要：
T细胞受体（TR），T细胞的抗原受体，特异性识别主要组织相容性（MH）蛋白呈递的肽，作为肽/MH（pMH），在细胞表面。三分子TR/pMH复合物的结构表征对免疫学领域至关重要。疫苗接种,和免疫疗法。IMGT/3Dstructure-DB是IMGT®的三维（3-D）结构数据库，国际ImMunoGenetics信息系统®。通过它的创造，IMGT®标志着免疫信息学的出现，出现在免疫遗传学和生物信息学之间的界面。IMGT®免疫球蛋白（IG）和TR基因和等位基因命名法（分类公理）以及IMGT独特编号和IMGT/Collier-de-Perles（编号公理）是免疫信息学的两个开创性突破。根据这些公理生成的IMGT-OnTOLOGY概念和IMGT科学图表规则允许IMGT®桥接基因，结构,和功能。IMGT/3Dstructure-DB包含IG或抗体的3-D结构，颌骨脊椎动物（gnathostomata）的适应性免疫反应的TR和MH蛋白，IG或TR与抗原的复合物（IG/Ag，TR/pMH),属于IG和MH超家族的任何物种的免疫系统的相关蛋白质，和用于免疫应用的融合蛋白。本章的重点是TR一V域和MH一G域的接触剖析和TR/pMH互相感化的比拟。标准化的分子表征包括肽和MH沟相互作用的“IMGTpMH接触位点”和TR/pMH复合物的“IMGT互补表位和表位”。数据在IMGT/3Dstructure数据库中可用，在IMGT主页http://www.imgt.org.
