METHODS: An open label, single arm clinical trial was conducted on participants with dry, photoaged, or dull skin. A defensin-containing hand and body cream was applied twice daily for 6 weeks to the hands, forearms, elbows, and knees. Photographs and objective measurements of skin hydration, viscoelasticity (VE), retraction time (RT), thickness, density/transepidermal water loss (TEWL), as well as self-evaluation of skin quality and characteristics were obtained pre- and post- intervention.
RESULTS: After the study period, RT decreased by 56% across all body sites (p < 0.001) and VE improved at the elbow (125%, p = 0.009) and knee (110%, p < 0.001). Skin density also increased in all 4 body sites (40%, p < 0.001), while skin thickness increased at the elbow (29%, p = 0.03) and knee (17%, p = 0.04). Skin hydration increased at the elbow, knee, and forearm by 99%, 28%, and 16%, respectively (p < 0.05), while TEWL improved at the elbow only (-39%, p = 0.02). Patients\' self-evaluations showed improvements in overall skin quality and in the domains of dryness, ashiness, wrinkling, pigmentation, redness, roughness, and discomfort (p < 0.05).
CONCLUSIONS: Following 6-week use of a defensin-containing cream, subjects reported significant improvement across many subjective skin domains. Similarly, objective measurements demonstrated significant improvement in skin architecture at select sites.
方法:开放标签,单臂临床试验是对干燥的参与者进行的,照片老化,或暗沉的皮肤。含防卫素的手部和身体霜每天两次,持续6周。前臂,肘部,和膝盖。皮肤水合的照片和客观测量,粘弹性(VE),缩回时间(RT),厚度,密度/经皮水分流失(TEWL),以及干预前后皮肤质量和特征的自我评价。
结果:研究结束后,所有身体部位的RT下降了56%(p<0.001),肘部的VE改善了(125%,p=0.009)和膝盖(110%,p<0.001)。所有4个身体部位的皮肤密度也增加了(40%,p<0.001),而肘部皮肤厚度增加(29%,p=0.03)和膝盖(17%,p=0.04)。肘部的皮肤水合作用增加,膝盖,和前臂99%,28%,16%,分别为(p<0.05),而TEWL仅在肘部有所改善(-39%,p=0.02)。患者的自我评估显示,在整体皮肤质量和干燥领域的改善,灰,起皱,色素沉着,发红,粗糙度,和不适(p<0.05)。
结论:使用含防御素的乳膏6周后,受试者报告了许多主观皮肤领域的显着改善。同样,客观测量显示,选定部位的皮肤结构有显著改善.