PDF(Pubmed)
Abstract：
UNASSIGNED: The most common etiologies of Cushing\'s syndrome (CS) are adrenocorticotropic hormone (ACTH)-producing pituitary adenoma (pitCS) and primary adrenal gland disease (adrCS), both of which burden patients with metabolic disturbance. The aim of this study was to compare the metabolic features of pitCS and adrCS patients.
UNASSIGNED: A retrospective review including 114 patients (64 adrCS and 50 pitCS) diagnosed with CS in 2009-2019 was performed. Metabolic factors were then compared between pitCS and adrCS groups.
UNASSIGNED: Regarding sex, females suffered both adrCs (92.2%) and pitCS (88.0%) more frequently than males. Regarding age, patients with pitCS were diagnosed at a younger age (35.40 ± 11.94 vs. 39.65 ± 11.37 years, p = 0.056) than those with adrCS, although the difference was not statistically significant. Moreover, pitCS patients had much higher ACTH levels and more serious occurrences of hypercortisolemia at all time points (8 AM, 4 PM, 12 AM) than that in adrCS patients. Conversely, indexes, including body weight, BMI, blood pressure, serum total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides, fasting plasma glucose, and uric acid, showed no differences between adrCS and pitCS patients. Furthermore, diabetes prevalence was higher in pitCS patients than in adrCS patients; however, there were no significant differences in hypertension or dyslipidemia prevalence between the two.
UNASSIGNED: Although adrCS and pitCS had different pathogenetic mechanisms, different severities of hypercortisolemia, and different diabetes prevalences, both etiologies had similar metabolic characteristics.
UNASSIGNED: A retrospective review including 114 patients (64 adrCS and 50 pitCS) diagnosed with CS in 2009-2019 was performed. Metabolic factors were then compared between pitCS and adrCS groups.
UNASSIGNED: Regarding sex, females suffered both adrCs (92.2%) and pitCS (88.0%) more frequently than males. Regarding age, patients with pitCS were diagnosed at a younger age (35.40 ± 11.94 vs. 39.65 ± 11.37 years, p = 0.056) than those with adrCS, although the difference was not statistically significant. Moreover, pitCS patients had much higher ACTH levels and more serious occurrences of hypercortisolemia at all time points (8 AM, 4 PM, 12 AM) than that in adrCS patients. Conversely, indexes, including body weight, BMI, blood pressure, serum total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides, fasting plasma glucose, and uric acid, showed no differences between adrCS and pitCS patients. Furthermore, diabetes prevalence was higher in pitCS patients than in adrCS patients; however, there were no significant differences in hypertension or dyslipidemia prevalence between the two.
UNASSIGNED: Although adrCS and pitCS had different pathogenetic mechanisms, different severities of hypercortisolemia, and different diabetes prevalences, both etiologies had similar metabolic characteristics.
摘要：
未经证实：库欣综合征（CS）最常见的病因是产生促肾上腺皮质激素（ACTH）的垂体腺瘤（pitCS）和原发性肾上腺疾病（adrCS）。两者都会给患者带来代谢紊乱的负担。这项研究的目的是比较pitCS和adrCS患者的代谢特征。
UNASSIGNED：进行了回顾性审查，包括2009-2019年诊断为CS的114例患者（64例adrCS和50例pitCS）。然后比较pitCS和adrCS组之间的代谢因素。
未经批准：关于性，女性患adrc（92.2％）和pitCS（88.0％）的频率高于男性。关于年龄,pitCS患者的诊断年龄较小（35.40±11.94vs.39.65±11.37岁，p=0.056)比那些有adrCS的，尽管差异无统计学意义。此外，pitCS患者在所有时间点都有更高的ACTH水平和更严重的高皮质醇血症发生（上午8点，4PM,12AM）比adrCS患者。相反，索引，包括体重,BMI,血压,血清总胆固醇,低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL-C），甘油三酯，空腹血糖，和尿酸，显示adrCS和pitCS患者之间没有差异。此外，pitCS患者的糖尿病患病率高于adrCS患者；然而，两者在高血压或血脂异常患病率方面无显著差异.
未经评估：尽管adrCS和pitCS具有不同的发病机制，不同严重程度的皮质醇血症，和不同的糖尿病患病率，两种病因具有相似的代谢特征.
UNASSIGNED：进行了回顾性审查，包括2009-2019年诊断为CS的114例患者（64例adrCS和50例pitCS）。然后比较pitCS和adrCS组之间的代谢因素。
未经批准：关于性，女性患adrc（92.2％）和pitCS（88.0％）的频率高于男性。关于年龄,pitCS患者的诊断年龄较小（35.40±11.94vs.39.65±11.37岁，p=0.056)比那些有adrCS的，尽管差异无统计学意义。此外，pitCS患者在所有时间点都有更高的ACTH水平和更严重的高皮质醇血症发生（上午8点，4PM,12AM）比adrCS患者。相反，索引，包括体重,BMI,血压,血清总胆固醇,低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL-C），甘油三酯，空腹血糖，和尿酸，显示adrCS和pitCS患者之间没有差异。此外，pitCS患者的糖尿病患病率高于adrCS患者；然而，两者在高血压或血脂异常患病率方面无显著差异.
未经评估：尽管adrCS和pitCS具有不同的发病机制，不同严重程度的皮质醇血症，和不同的糖尿病患病率，两种病因具有相似的代谢特征.
