Abstract：
BACKGROUND: Factor V Leiden (FVL) is a hereditary thrombophilia, which causes the blood to be more hypercoagulable; in essence, the blood tends to clot more easily, especially under certain circumstances. It is the most common genetic mutation, causing thrombophilia in patients of white background. Patients that have FVL are at a higher risk to develop venous thromboembolism (VTE) after surgery and trauma.
OBJECTIVE: The purpose of this review is to identify FVL as a risk factor, which may impede optimum acute cardiopulmonary management which may contribute to a longer length of stay (LOS) in the hospital.
METHODS: This article is a systematic review of the literature involving research printed in peer-reviewed journals from 2015 to 2018. The University of Tennessee Health Science Center online library, PubMed, and Google Scholar were used for the literature search.
RESULTS: The results of this study determined that although FVL is in fact a risk factor, which may impede optimum acute cardiopulmonary management which may contribute to a longer LOS, management of VTE is no different for a person with FVL compared with those without FVL.
CONCLUSIONS: Factor V Leiden is a risk factor for the development of VTE, specifically deep vein thrombosis, in surgical, trauma, pregnant, and hormone replacement therapy patients, thus increasing LOS and recurrence of such events. Regardless of FVL status, management of VTE should be initiated promptly and discontinued when appropriate.
OBJECTIVE: The purpose of this review is to identify FVL as a risk factor, which may impede optimum acute cardiopulmonary management which may contribute to a longer length of stay (LOS) in the hospital.
METHODS: This article is a systematic review of the literature involving research printed in peer-reviewed journals from 2015 to 2018. The University of Tennessee Health Science Center online library, PubMed, and Google Scholar were used for the literature search.
RESULTS: The results of this study determined that although FVL is in fact a risk factor, which may impede optimum acute cardiopulmonary management which may contribute to a longer LOS, management of VTE is no different for a person with FVL compared with those without FVL.
CONCLUSIONS: Factor V Leiden is a risk factor for the development of VTE, specifically deep vein thrombosis, in surgical, trauma, pregnant, and hormone replacement therapy patients, thus increasing LOS and recurrence of such events. Regardless of FVL status, management of VTE should be initiated promptly and discontinued when appropriate.
摘要：
背景：因子V莱顿（FVL）是一种遗传性血栓形成倾向，这导致血液更加高凝；本质上，血液更容易凝结，尤其是在某些情况下。这是最常见的基因突变,在白色背景的患者中引起血栓形成倾向。患有FVL的患者在手术和创伤后发生静脉血栓栓塞(VTE)的风险较高。
目的：本综述的目的是确定FVL为危险因素，这可能会阻碍最佳的急性心肺管理，这可能会导致住院时间更长（LOS）。
方法：本文是对2015年至2018年在同行评审期刊上印刷的研究的文献的系统回顾。田纳西大学健康科学中心在线图书馆，PubMed,和谷歌学者被用于文献检索。
结果：这项研究的结果确定，尽管FVL实际上是一个危险因素，这可能会阻碍最佳的急性心肺管理，这可能会导致更长的LOS，与没有FVL的人相比，患有FVL的人的VTE管理没有什么不同。
结论：因子VLeiden是VTE发展的危险因素，特别是深静脉血栓,在外科，创伤,怀孕,激素替代疗法的病人,从而增加LOS和此类事件的复发。不管FVL状态如何，VTE的管理应及时启动，并在适当时停止。
目的：本综述的目的是确定FVL为危险因素，这可能会阻碍最佳的急性心肺管理，这可能会导致住院时间更长（LOS）。
方法：本文是对2015年至2018年在同行评审期刊上印刷的研究的文献的系统回顾。田纳西大学健康科学中心在线图书馆，PubMed,和谷歌学者被用于文献检索。
结果：这项研究的结果确定，尽管FVL实际上是一个危险因素，这可能会阻碍最佳的急性心肺管理，这可能会导致更长的LOS，与没有FVL的人相比，患有FVL的人的VTE管理没有什么不同。
结论：因子VLeiden是VTE发展的危险因素，特别是深静脉血栓,在外科，创伤,怀孕,激素替代疗法的病人,从而增加LOS和此类事件的复发。不管FVL状态如何，VTE的管理应及时启动，并在适当时停止。
