PDF(Pubmed)
Abstract：
Recent studies have revealed that circRNAs can affect tumor DNA damage and repair, apoptosis, proliferation, and invasion and influence the transport of intratumor substances by acting as miRNA sponges and transcriptional regulators and binding to proteins in a variety of ways. However, research on the role of circRNAs in cancer radiotherapy and chemoresistance is still in its early stages. Chemotherapy is a common approach to oncology treatment, but the development of tumor resistance limits the overall clinical efficacy of chemotherapy for cancer patients. The current study suggests that circRNAs have a facilitative or inhibitory effect on the development of resistance to conventional chemotherapy in a variety of tumors, suggesting that circRNAs may serve as a new direction for the study of antitumor drug resistance. In this review, we will briefly discuss the biological features of circRNAs and summarize the recent progression of the involvement of circRNAs in the development and pathogenesis of cancer chemoresistance.
摘要：
最近的研究表明，circRNAs可以影响肿瘤DNA损伤和修复，凋亡，扩散,以及通过充当miRNA海绵和转录调节因子并以多种方式与蛋白质结合来影响肿瘤内物质的侵袭和转运。然而,关于circRNAs在癌症放疗和化疗耐药中的作用的研究仍处于早期阶段。化疗是肿瘤治疗的常用方法,但是肿瘤耐药的发展限制了化疗对癌症患者的整体临床疗效。目前的研究表明，circRNAs对多种肿瘤对常规化疗耐药的发展具有促进作用或抑制作用，circRNAs可能成为抗肿瘤耐药研究的新方向。在这次审查中,我们将简要讨论circRNAs的生物学特征，并总结circRNAs参与癌症化疗耐药的发展和发病机制的最新进展。
