PDF(Pubmed)
Abstract：
STX17 (syntaxin 17) mediates autophagosome-lysosome fusion, and the translocation of STX17 to autophagosomes is characteristic of this process. STX17 arrives at autophagosomes when they are closed, stays there for approximately 10 min to promote fusion with lysosomes, and leaves when the autolysosomes are mature. However, the mechanism of this transient visit remains largely unknown. Here, we summarize the current knowledge about this phenomenon, including a recently discovered retrieval mechanism, and discuss remaining questions.Abbreviations: MAM: mitochondria-associated membrane; SNX: sorting nexin; STX17: syntaxin 17.
摘要：
STX17（syntaxin17）介导自噬体-溶酶体融合，STX17向自噬体的易位是这个过程的特征。STX17在自噬体关闭时到达，在那里停留大约10分钟以促进与溶酶体融合，并在自溶酶体成熟时离开。然而,这种短暂访问的机制仍然未知。这里,我们总结了目前关于这种现象的知识，包括最近发现的检索机制，讨论剩下的问题。缩写:MAM:线粒体相关膜;SNX:分选nexin;STX17:syntaxin17。
