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Abstract：
Human C-type lectin-like CD161 is a type-II transmembrane protein expressed on the surface of various lymphocytes across innate and adaptive immune systems. CD161+ T cells displayed enhanced ability to produce cytokines and were shown to be enriched in the gut. Independently of function, CD161 was used as marker of innate-like T cells and marker of IL-17-producing cells. The function of CD161 is still not fully understood. In T cells, CD161 was proposed to act as co-signalling receptor that influence T-cell receptor-dependent responses. However, conflicting studies were published demonstrating lack of agreement over the role of CD161 during T-cell activation. In this review, we outline phenotypical and functional consequences of CD161 expression in T cells. We provide critical discussion over the most pressing issues including in depth evaluation of the literature concerning CD161 putative co-signalling properties.
摘要：
人C型凝集素样CD161是在先天和适应性免疫系统中的各种淋巴细胞表面上表达的II型跨膜蛋白。CD161+T细胞显示增强的产生细胞因子的能力,并且显示在肠道中富集。独立于功能，CD161用作先天样T细胞的标志物和产生IL-17的细胞的标志物。CD161的功能尚未完全了解。在T细胞中,CD161被提议充当影响T细胞受体依赖性应答的共信号传导受体。然而,发表的相互矛盾的研究表明,对于CD161在T细胞活化过程中的作用缺乏共识.在这次审查中,我们概述了T细胞中CD161表达的表型和功能后果。我们对最紧迫的问题进行了批判性讨论，包括对有关CD161推定的共信号传导特性的文献进行了深入评估。
