PDF(Pubmed)
Abstract：
BACKGROUND: Cladosporium and Corynespora cassiicola (C. cassiicola) infections rarely occur in humans. Mutations in human caspase recruitment domain protein 9 (CARD9) are reported to be associated with fungal diseases. Pulmonary Cladosporium infection coexisting with subcutaneous C. cassiicola infection in a patient with a CARD9 mutation has not been reported in the literature.
METHODS: A 68-year-old male patient was hospitalized for hypertrophic erythema and deep ulcers on the left upper extremity. He was diagnosed with pneumonia caused by Cladosporium, as identified through bronchoalveolar lavage fluid analysis, and deep dermatophytosis caused by C. cassiicola, as identified through morphological characteristics of the wound secretion culture. He underwent antifungal therapy (voriconazole) and recovered successfully. He carried two mutations in CARD9 (chr9:139266425 and chr9:139262240) and was therefore susceptible to fungal infections.
CONCLUSIONS: This case study is the first to report the coexistence of pulmonary Cladosporium infection and subcutaneous C. cassiicola infection in a patient with CARD9 mutation. Our findings will be helpful in enriching the phenotypic spectrum of fungal infections underlying CARD9 deficiency.
METHODS: A 68-year-old male patient was hospitalized for hypertrophic erythema and deep ulcers on the left upper extremity. He was diagnosed with pneumonia caused by Cladosporium, as identified through bronchoalveolar lavage fluid analysis, and deep dermatophytosis caused by C. cassiicola, as identified through morphological characteristics of the wound secretion culture. He underwent antifungal therapy (voriconazole) and recovered successfully. He carried two mutations in CARD9 (chr9:139266425 and chr9:139262240) and was therefore susceptible to fungal infections.
CONCLUSIONS: This case study is the first to report the coexistence of pulmonary Cladosporium infection and subcutaneous C. cassiicola infection in a patient with CARD9 mutation. Our findings will be helpful in enriching the phenotypic spectrum of fungal infections underlying CARD9 deficiency.
摘要：
背景：枝孢菌和cassiicola念珠菌（C.cassiicola）感染很少发生在人类中。据报道，人胱天蛋白酶募集结构域蛋白9（CARD9）的突变与真菌疾病相关。在具有CARD9突变的患者中，肺枝孢菌感染与皮下念珠菌感染并存的文献尚未报道。
方法：一名68岁男性患者因增生性红斑和左上肢深部溃疡住院。他被诊断出由枝孢菌引起的肺炎,通过支气管肺泡灌洗液分析确定，和由C.cassiicola引起的深部皮肤癣菌病，通过伤口分泌物培养物的形态特征鉴定。他接受了抗真菌治疗（伏立康唑）并成功康复。他在CARD9中携带两个突变（chr9：139266425和chr9：139262240），因此对真菌感染易感。
结论：本病例研究首次报道了1例CARD9突变患者肺部枝状孢子菌感染和皮下念珠菌感染并存的情况。我们的发现将有助于丰富CARD9缺乏的真菌感染的表型谱。
方法：一名68岁男性患者因增生性红斑和左上肢深部溃疡住院。他被诊断出由枝孢菌引起的肺炎,通过支气管肺泡灌洗液分析确定，和由C.cassiicola引起的深部皮肤癣菌病，通过伤口分泌物培养物的形态特征鉴定。他接受了抗真菌治疗（伏立康唑）并成功康复。他在CARD9中携带两个突变（chr9：139266425和chr9：139262240），因此对真菌感染易感。
结论：本病例研究首次报道了1例CARD9突变患者肺部枝状孢子菌感染和皮下念珠菌感染并存的情况。我们的发现将有助于丰富CARD9缺乏的真菌感染的表型谱。
