Abstract：
BACKGROUND: Profound uterine relaxation is required for open fetal surgery. This is typically achieved by the administration of high-dose halogenated anesthetic agents. However, this anesthetic technique is associated with adverse cardiovascular effects in the fetus and may have long-term neurocognitive effects as well.
METHODS: We pre-sent reports for 2 patients in whom uterine relaxation was maintained with nitroglycerin and magnesium infusions without any exposure to halogenated anesthetic agents. There were no adverse fetal or maternal effects from this technique.
CONCLUSIONS: To the best of our knowledge, these are the first reports of open fetal surgery being performed without the use of halogenated anesthetic agents. This has potential short- and long-term benefits for the fetus, particularly as more complex and longer duration minimally invasive procedures are developed.
METHODS: We pre-sent reports for 2 patients in whom uterine relaxation was maintained with nitroglycerin and magnesium infusions without any exposure to halogenated anesthetic agents. There were no adverse fetal or maternal effects from this technique.
CONCLUSIONS: To the best of our knowledge, these are the first reports of open fetal surgery being performed without the use of halogenated anesthetic agents. This has potential short- and long-term benefits for the fetus, particularly as more complex and longer duration minimally invasive procedures are developed.
摘要：
背景：胎儿开放手术需要深度子宫松弛。这通常通过施用高剂量卤化麻醉剂来实现。然而,这种麻醉技术与胎儿的心血管不良反应相关,也可能具有长期的神经认知效应.
方法：我们为2例接受硝酸甘油和镁输注维持子宫松弛而未接触任何卤化麻醉剂的患者提供报告。该技术没有不良的胎儿或母体影响。
结论：据我们所知，这些是在不使用卤化麻醉剂的情况下进行开放式胎儿手术的首次报道。这对胎儿有潜在的短期和长期益处，特别是随着更复杂和持续时间更长的微创手术的发展。
方法：我们为2例接受硝酸甘油和镁输注维持子宫松弛而未接触任何卤化麻醉剂的患者提供报告。该技术没有不良的胎儿或母体影响。
结论：据我们所知，这些是在不使用卤化麻醉剂的情况下进行开放式胎儿手术的首次报道。这对胎儿有潜在的短期和长期益处，特别是随着更复杂和持续时间更长的微创手术的发展。
