PDF(Pubmed)
Abstract：
UNASSIGNED: Although Arm circumference (AC) is considered to be a predictor of clinical outcomes of transcatheter aortic valve replacement (TAVR), limited data are available on the impact of this anthropometric measurement. This study aimed to investigate the clinical impact of AC on the outcomes of patients who underwent TAVR.
UNASSIGNED: AC was investigated in consecutive patients who underwent TAVR between March 2014 and May 2018. Patients were divided into low AC (n = 220) and high AC (n = 127) groups by a classification and regression tree (CART) survival model, and their baseline characteristics and mortality were compared. The correlations of AC with other frailty markers were also evaluated.
UNASSIGNED: One-year clinical follow-up was completed in 100% of cases, and 89 patients (31 men, 58 women) died during the median follow-up period of 825 days. The low AC group was more fragile than the high AC group, and the AC value was significantly correlated with each frailty marker (all p < 0.05). The Cox regression analysis demonstrated the independent association of mortality with low AC (HR: 2.56, 95% confidence interval [CI]: 1.47-4.46, p < 0.001). When AC was compared to conventional prediction models of survival, the net reclassification improvement and the integrated discrimination improvement analysis showed significant improvements in predicting outcomes after including the AC with other frailty markers (all p < 0.05).
UNASSIGNED: The AC is related to frailty markers and is an important surrogate marker for predicting worse clinical outcomes after TAVR. Assessment of AC may be considered when deciding on TAVR.
UNASSIGNED: AC was investigated in consecutive patients who underwent TAVR between March 2014 and May 2018. Patients were divided into low AC (n = 220) and high AC (n = 127) groups by a classification and regression tree (CART) survival model, and their baseline characteristics and mortality were compared. The correlations of AC with other frailty markers were also evaluated.
UNASSIGNED: One-year clinical follow-up was completed in 100% of cases, and 89 patients (31 men, 58 women) died during the median follow-up period of 825 days. The low AC group was more fragile than the high AC group, and the AC value was significantly correlated with each frailty marker (all p < 0.05). The Cox regression analysis demonstrated the independent association of mortality with low AC (HR: 2.56, 95% confidence interval [CI]: 1.47-4.46, p < 0.001). When AC was compared to conventional prediction models of survival, the net reclassification improvement and the integrated discrimination improvement analysis showed significant improvements in predicting outcomes after including the AC with other frailty markers (all p < 0.05).
UNASSIGNED: The AC is related to frailty markers and is an important surrogate marker for predicting worse clinical outcomes after TAVR. Assessment of AC may be considered when deciding on TAVR.
摘要：
UASSIGNED：尽管臂围（AC）被认为是经导管主动脉瓣置换术（TAVR）的临床结果的预测指标，关于这种人体测量的影响的数据有限。本研究旨在探讨AC对接受TAVR的患者预后的临床影响。
UNASSIGNED：在2014年3月至2018年5月期间接受TAVR的连续患者中对AC进行了调查。通过分类和回归树（CART）生存模型将患者分为低AC（n=220）和高AC（n=127）组。并比较其基线特征和死亡率.还评估了AC与其他虚弱标记的相关性。
UNASSIGNED：在100％的病例中完成了一年的临床随访，和89名患者(31名男性，58名妇女）在825天的中位随访期内死亡。低AC组比高AC组更脆弱，AC值与各衰弱标志物呈显著相关(均p<0.05)。Cox回归分析显示死亡率与低AC的独立关联(HR:2.56,95%置信区间[CI]:1.47-4.46,p<0.001)。当将AC与传统的生存预测模型进行比较时，净重新分类改善和综合辨别改善分析显示,在将AC与其他虚弱标记物一起纳入后,在预测结局方面有显著改善(均p<0.05).
UNASSIGNED：AC与虚弱标志物相关，是预测TAVR后不良临床结局的重要替代标志物。在决定TAVR时可以考虑AC的评估。
UNASSIGNED：在2014年3月至2018年5月期间接受TAVR的连续患者中对AC进行了调查。通过分类和回归树（CART）生存模型将患者分为低AC（n=220）和高AC（n=127）组。并比较其基线特征和死亡率.还评估了AC与其他虚弱标记的相关性。
UNASSIGNED：在100％的病例中完成了一年的临床随访，和89名患者(31名男性，58名妇女）在825天的中位随访期内死亡。低AC组比高AC组更脆弱，AC值与各衰弱标志物呈显著相关(均p<0.05)。Cox回归分析显示死亡率与低AC的独立关联(HR:2.56,95%置信区间[CI]:1.47-4.46,p<0.001)。当将AC与传统的生存预测模型进行比较时，净重新分类改善和综合辨别改善分析显示,在将AC与其他虚弱标记物一起纳入后,在预测结局方面有显著改善(均p<0.05).
UNASSIGNED：AC与虚弱标志物相关，是预测TAVR后不良临床结局的重要替代标志物。在决定TAVR时可以考虑AC的评估。
