Abstract：
OBJECTIVE: Several randomized-controlled trials (RCTs) were performed to compare the efficacy of sexual intercourse or masturbation and no sexual activity in treating distal ureteral stones, indicating conflicting results. The meta-analysis was conducted to assess the role of sexual intercourse or masturbation in the treatment of distal ureteral calculi.
METHODS: PubMed, Cochrane Library, EMBASE, Scopus, Clinicaltrail.gov, and Web of Science were searched by October 2021. Men who were instructed of no sexual intercourse or masturbation, and only received standard symptomatic treatment are comparators. Relative risk (RR), weighted mean difference (WMD), and their 95% confidence intervals (CIs) were calculated using random or fixed effects models.
RESULTS: Five RCTs including 500 subjects were analyzed in the study. Compared with controls, subjects in experimental group had significantly higher expulsion rate at 2nd and 4th week (95%CI: 1.334 to 2.638, RR: 1.876, I2 = 73.6%, P < .001; 95%CI: 1.148 to 1.752, RR: 1.418, I2 = 55.9%, P < .001), significantly decreased requirement for analgesic injections (95%CI: -1.071 to -.126, WMD: -.598, I2 = 90.3%, P = .013), and significantly shorter expulsion time (95%CI: -6.941 to -.436, WMD: -3.689, I2 = 83.7%, P = .026).
CONCLUSIONS: Performing sexual intercourse or masturbation 3 or 4 times a week can be an alternative treatment option of distal ureteral calculi (0-10 mm in size). However, more clinical evidence with better designs solving raised concerns is warranted.
METHODS: PubMed, Cochrane Library, EMBASE, Scopus, Clinicaltrail.gov, and Web of Science were searched by October 2021. Men who were instructed of no sexual intercourse or masturbation, and only received standard symptomatic treatment are comparators. Relative risk (RR), weighted mean difference (WMD), and their 95% confidence intervals (CIs) were calculated using random or fixed effects models.
RESULTS: Five RCTs including 500 subjects were analyzed in the study. Compared with controls, subjects in experimental group had significantly higher expulsion rate at 2nd and 4th week (95%CI: 1.334 to 2.638, RR: 1.876, I2 = 73.6%, P < .001; 95%CI: 1.148 to 1.752, RR: 1.418, I2 = 55.9%, P < .001), significantly decreased requirement for analgesic injections (95%CI: -1.071 to -.126, WMD: -.598, I2 = 90.3%, P = .013), and significantly shorter expulsion time (95%CI: -6.941 to -.436, WMD: -3.689, I2 = 83.7%, P = .026).
CONCLUSIONS: Performing sexual intercourse or masturbation 3 or 4 times a week can be an alternative treatment option of distal ureteral calculi (0-10 mm in size). However, more clinical evidence with better designs solving raised concerns is warranted.
摘要：
目的：进行了几项随机对照试验（RCT），以比较性交或手淫和无性活动治疗输尿管远端结石的疗效。表明冲突的结果。进行荟萃分析以评估性交或手淫在输尿管远端结石治疗中的作用。
方法：PubMed，科克伦图书馆,EMBASE,Scopus,Clinicaltrail.gov,和WebofScience在2021年10月之前进行了搜索。被指示没有性交或手淫的男人，仅接受标准对症治疗是比较。相对风险(RR)，加权平均差(WMD)，他们的95%置信区间(CI)使用随机或固定效应模型计算。
结果：在研究中分析了包括500名受试者在内的5个随机对照试验。与对照组相比，实验组的受试者在第2周和第4周的驱逐率明显更高（95CI：1.334至2.638，RR：1.876，I2=73.6％，P<.001；95CI：1.148至1.752，RR：1.418，I2=55.9%，P<.001),止痛剂注射的需求显着降低（95CI：-1.071至-.126，大规模杀伤性武器：-.598，I2=90.3%，P=.013)，驱逐时间明显缩短（95CI：-6.941至-.436，大规模杀伤性武器：-3.689，I2=83.7%，P=.026）。
结论：每周进行3或4次性交或手淫可以作为输尿管远端结石（0-10毫米大小）的替代治疗选择。然而,有必要提供更多的临床证据和更好的设计来解决所引起的问题.
方法：PubMed，科克伦图书馆,EMBASE,Scopus,Clinicaltrail.gov,和WebofScience在2021年10月之前进行了搜索。被指示没有性交或手淫的男人，仅接受标准对症治疗是比较。相对风险(RR)，加权平均差(WMD)，他们的95%置信区间(CI)使用随机或固定效应模型计算。
结果：在研究中分析了包括500名受试者在内的5个随机对照试验。与对照组相比，实验组的受试者在第2周和第4周的驱逐率明显更高（95CI：1.334至2.638，RR：1.876，I2=73.6％，P<.001；95CI：1.148至1.752，RR：1.418，I2=55.9%，P<.001),止痛剂注射的需求显着降低（95CI：-1.071至-.126，大规模杀伤性武器：-.598，I2=90.3%，P=.013)，驱逐时间明显缩短（95CI：-6.941至-.436，大规模杀伤性武器：-3.689，I2=83.7%，P=.026）。
结论：每周进行3或4次性交或手淫可以作为输尿管远端结石（0-10毫米大小）的替代治疗选择。然而,有必要提供更多的临床证据和更好的设计来解决所引起的问题.
