Abstract：
Carbohydrate polymers with unique chemical composition, molecular weight and functional chemical groups show multiple potentials in drug delivery. Most carbohydrate polymers such as plant polysaccharides exhibit advantages of biodegradability, ease of modification, low immunogenicity and low toxicity. They can be conjugated, cross-linked or functionally modified, and then used as nanocarrier materials. Polysaccharide drug delivery system can avoid the phagocytosis of the reticuloendothelial system, prevent the degradation of biomolecules, and increase the bioavailability of small molecules, thus exerting effective therapeutic effects. Therefore, they have been fully explored. In this paper, we reviewed the construction methods of drug delivery systems based on carbohydrate polymers (astragalus polysaccharide, angelica polysaccharide, lycium barbarum polysaccharide, ganoderma lucidum polysaccharide, bletilla polysaccharide, glycyrrhiza polysaccharide, and epimedium polysaccharides, etc). The application of polysaccharide drug delivery systems to deliver small molecule chemotherapeutic drugs, gene drugs, and metal ion drugs was also briefly introduced. At the same time, the role of the polysaccharide drug delivery system in tumor treatment, targeted therapy, and wound healing was discussed. In addition, the research of polysaccharide delivery systems based on the therapeutic efficacy of traditional Chinese medicine was also summarized and prospected.
摘要：
具有独特化学成分的碳水化合物聚合物，分子量和功能化学基团在药物递送中显示出多种潜力。大多数碳水化合物聚合物如植物多糖表现出生物降解性的优点，易于修改，低免疫原性和低毒性。它们可以共轭，交联或功能修饰，然后用作纳米载体材料。多糖给药系统可以避免网状内皮系统的吞噬作用，防止生物分子的降解，增加小分子的生物利用度，从而发挥有效的治疗作用。因此,他们已经得到了充分的探索。在本文中,我们综述了基于碳水化合物聚合物（黄芪多糖，当归多糖，枸杞多糖，灵芝多糖，白名单多糖，甘草多糖，和淫羊藿多糖，etc).多糖药物递送系统在小分子化疗药物递送中的应用,基因药物，并简要介绍了金属离子药物。同时,多糖给药系统在肿瘤治疗中的作用,靶向治疗,并讨论了伤口愈合。此外,对基于中药疗效的多糖给药系统的研究进行了总结和展望。
